Linocaine Hydrochloride, also widely known as Lidocaine Hydrochloride or Lidocaine HCl, is a cornerstone active pharmaceutical ingredient (API) with a critical role in modern medicine. Identified by its CAS number 6108-05-0, this compound is primarily utilized for its powerful local anesthetic and antiarrhythmic properties. As a white crystalline powder, High Purity Linocaine Hydrochloride is a vital raw material for the production of various pharmaceutical formulations used globally.

The efficacy and safety of medicinal products containing Linocaine Hydrochloride are directly dependent on the quality and purity of the API used in their manufacture. Achieving a purity level of 99% or higher is paramount to meet the stringent requirements of pharmacopoeial standards such as USP and BP, ensuring that final drug products are safe, effective, and consistent.

Local Anesthetic Applications

Linocaine Hydrochloride functions as an amide-type local anesthetic by blocking voltage-gated sodium channels in neuronal cell membranes. This action prevents the initiation and propagation of action potentials, thereby interrupting nerve impulse transmission. The result is a temporary loss of sensation or pain perception in a specific area of the body without affecting consciousness. This property makes it invaluable in a wide range of medical and dental procedures.

Its anesthetic applications include:

1. Infiltration Anesthesia: Injecting the solution directly into the tissues surrounding the surgical site to numb a small area. This is commonly used for minor surgical procedures, biopsies, and dental work.

2. Epidural Anesthesia: Administering into the epidural space around the spinal cord. This technique is widely used for pain management during labor and delivery, as well as for certain surgical procedures and chronic pain relief.

3. Surface Anesthesia: Applying topically to mucous membranes or skin to provide superficial numbing. This is useful for procedures involving the mouth, nose, throat, respiratory tract (e.g., during bronchoscopy or thoracoscopy), and genitourinary tract (e.g., during cystoscopy). The material specifically mentions its use for mucosal anesthesia during thoracoscopy or abdominal surgery, highlighting its utility in internal applications.

4. Nerve Block: Injecting near specific nerves or nerve plexuses to block sensation in a larger area supplied by those nerves. Examples include dental nerve blocks, intercostal nerve blocks, or brachial plexus blocks for upper limb surgery.

Compared to some other local anesthetics, Linocaine Hydrochloride has a relatively rapid onset and an intermediate duration of action, making it versatile for both short procedures and the initiation of longer-lasting blocks.

Antiarrhythmic Applications

Beyond its role in pain management, Linocaine Hydrochloride is classified as a Class IB antiarrhythmic drug. It exerts its effect on the heart by blocking cardiac sodium channels, particularly those in damaged or ischemic tissue. This mechanism helps to stabilize the cardiac membrane and reduce abnormal electrical activity that can lead to certain types of arrhythmias.

It is primarily used in the treatment of:

1. Ventricular Arrhythmias: Such as ventricular premature beats (VPBs) and ventricular tachycardia (VT). It is particularly effective in treating arrhythmias that occur in the setting of acute myocardial infarction (AMI) or following cardiac surgery.

2. Digitalis-Induced Arrhythmias: It can be effective in suppressing ventricular arrhythmias caused by toxicity from digitalis glycosides.

The material points out that Linocaine Hydrochloride is usually ineffective for supraventricular arrhythmias, underscoring its specific action on ventricular tissue. At therapeutic blood concentrations (typically 1-5 μg/mL), it reduces myocardial excitability without significantly slowing conduction velocity in healthy tissue. However, as highlighted in the source material, increased plasma concentration may cause slowing of heart conduction, atrioventricular block, inhibition of myocardial contractility and decreased cardiac output, while sub-poisoning plasma concentration can exhibit an anti-convulsive effect.

Quality and Manufacturing Excellence

Producing High Purity Linocaine Hydrochloride Powder requires sophisticated chemical synthesis and stringent quality control processes. Pharmaceutical manufacturers sourcing this API demand absolute confidence in its purity, consistency, and compliance with international pharmacopoeial standards. Impurities, even at low levels, can compromise the safety and efficacy of the final drug product, potentially leading to adverse effects in patients.

Key quality indicators include not only the assay purity (minimum 99.0% specified) but also limits on specific impurities, residual solvents, heavy metals, and microbial contamination. Robust analytical testing using validated methods (e.g., HPLC, GC, atomic absorption) is essential to verify these parameters for every batch.

Reliable API suppliers invest heavily in quality management systems, often adhering to principles equivalent to GMP (Good Manufacturing Practice) guidelines for API production, even if not producing the finished drug product itself. This commitment ensures traceability, consistency, and safety throughout the manufacturing process, from raw material sourcing to final packaging.

Sourcing High Purity Linocaine Hydrochloride (CAS 6108-05-0)

The global demand for High Purity Linocaine Hydrochloride Powder remains strong due to its widespread use in healthcare. Pharmaceutical companies, compounding pharmacies, and research institutions require a consistent and reliable supply of this critical API. Sourcing from experienced and reputable suppliers is crucial for maintaining the quality and compliance of their downstream products.

For pharmaceutical companies seeking a dependable manufacturer and supplier of High Purity Linocaine Hydrochloride Powder (CAS 6108-05-0), NINGBO INNO PHARMCHEM CO.,LTD. provides a trusted source. We are committed to delivering APIs that meet the highest quality standards required by the global pharmaceutical industry. Inquiring about the current price or initiating a purchase/buy process involves direct communication with our dedicated sales team. We facilitate the purchase of this essential API, ensuring compliance with international standards and providing necessary documentation to support our customers' regulatory requirements.

Choosing a partner like NINGBO INNO PHARMCHEM CO.,LTD. means selecting a supplier focused on quality, reliability, and customer service, essential factors when you need to buy critical APIs like Linocaine Hydrochloride. Our experience in the pharmaceutical chemical supply chain ensures that customers receive a high-quality product efficiently and securely, allowing them to focus on producing life-saving and pain-relieving medications.