(S)-1-对甲苯磺酰基-3-(1-氰基-1,1-二苯甲基)吡咯烷, also known by its CAS number 133099-09-9, is a crucial pharmaceutical intermediate recognized chemically as 3-(S)-(1-Cyano-1,1-diphenylmethyl)-1-tosylpyrrolidine or {(3S)-1-[(4-Methylphenyl)sulfonyl]pyrrolidin-3-yl}(diphenyl)acetonitrile. This compound is primarily utilized in the synthesis of Darifenacin and its hydrobromide salt, which are active pharmaceutical ingredients (APIs) used in the treatment of overactive bladder.

The material presents as a high-quality white crystalline powder, indicating a pure and refined substance essential for sensitive pharmaceutical processes. Its specification confirms an Assay of ≥99.0%, underscoring its suitability for demanding synthesis routes where impurity profiles are critical for the safety and efficacy of the final drug product.

Key physical and chemical properties include a molecular formula of C25H24N2O2S and a molecular weight of 416.535. Its density is approximately 1.2 g/cm³, with a reported boiling point around 582.8 °C and a flash point of 306.3 °C. These properties provide valuable information for handling, storage, and processing within a manufacturing environment. The high boiling and flash points suggest relative stability under normal conditions, although safe handling practices appropriate for fine chemicals are always recommended.

The primary application of CAS 133099-09-9 lies in its role as a pivotal building block for Darifenacin (CAS: 133099-04-4) and Darifenacin hydrobromide (CAS: 133099-07-7). Darifenacin is a muscarinic antagonist that acts selectively on the M₃ receptor, which is prevalent in the bladder. By blocking these receptors, it helps to reduce involuntary bladder contractions, thereby alleviating symptoms of overactive bladder such as urinary urgency, frequency, and urge incontinence. The quality and purity of the intermediate directly impact the yield, purity, and regulatory compliance of the final Darifenacin API.

Storage recommendations for this product specify keeping it in a cool, ventilated place. This standard practice helps maintain the integrity and stability of the powder over time, preventing degradation that could affect its assay and suitability for synthesis. The material is typically packaged in 25 kg drums, a common packaging size for pharmaceutical intermediates, facilitating bulk transport and storage for manufacturers.

Ensuring a consistent and reliable supply of high-purity (S)-1-Tosysl-3-(1-Cyano-1,1-diphenylmethyl)pyrrolidine is vital for pharmaceutical companies engaged in the production of Darifenacin. The availability of this critical intermediate from a trusted supplier can significantly impact manufacturing efficiency and cost-effectiveness. For companies seeking to buy or purchase this essential white crystalline powder, verifying the manufacturer's quality control processes and production capabilities is paramount. Obtaining competitive price structures for bulk orders is also a key consideration for procurement departments. Reliable supply sources offer detailed information on the product's specification, handling, and logistics to facilitate a smooth purchase process, ensuring that manufacturers have timely access to the high-quality raw materials needed to produce essential medicines like Darifenacin.