Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, commonly known as SMCC, with CAS No. 64987-85-5, is a crucial chemical intermediate widely utilized in complex organic synthesis, particularly within the pharmaceutical and biotechnology sectors. As a heterobifunctional crosslinker, SMCC possesses distinct reactive groups at opposite ends of its molecular structure, making it an indispensable tool for forming stable covalent linkages between different types of molecules. NINGBO INNO PHARMCHEM CO.,LTD. is proud to offer high-quality SMCC powder, meeting the stringent demands of various advanced applications.

Chemically, SMCC features an N-hydroxysuccinimide (NHS) ester group and a maleimide group. The NHS ester is highly reactive towards primary amines, typically found in lysine residues on proteins or the N-terminus of peptides. This reaction forms a stable amide bond. Simultaneously, the maleimide group specifically reacts with sulfhydryl groups (thiols), commonly found in cysteine residues. This reaction yields a stable thioether linkage. The presence of a cyclohexane ring within the molecule provides a rigid spacer arm and enhances the overall stability of the crosslinker and the resulting conjugate.

This dual reactivity allows SMCC to efficiently link molecules containing amine groups to molecules containing sulfhydryl groups. This capability is fundamental in numerous bioconjugation strategies. One of the most significant applications of SMCC is in the development of Antibody-Drug Conjugates (ADCs). ADCs require a stable linker to attach potent cytotoxic drugs to antibodies, ensuring targeted delivery to cancer cells. SMCC is frequently chosen for this purpose due to the stability of the maleimide-thiol bond, which is less prone to hydrolysis compared to linkers targeting lysines, minimizing premature drug release in circulation.

Beyond ADCs, SMCC is extensively used for modifying proteins and peptides. It enables the site-specific attachment of fluorescent dyes, biotin, enzymes, or other labels to antibodies or proteins through available thiols (often introduced by reducing disulfide bonds or through genetic engineering). This is vital for creating probes for diagnostic assays, Western blotting, ELISA, and immunohistochemistry. The ability to create well-defined conjugates with controlled stoichiometry is a major advantage offered by SMCC.

Another important area where SMCC plays a critical role is in the immobilization of biomolecules onto solid supports. Researchers and manufacturers use SMCC to covalently attach proteins, peptides, or nucleic acids to chromatography resins, magnetic beads, biosensor surfaces, or microplate wells. This immobilization is essential for developing affinity chromatography columns, diagnostic kits, solid-phase assays, and biosensors. The stable linkage ensures that the biomolecule remains securely attached during washing steps and repeated use.

NINGBO INNO PHARMCHEM CO.,LTD. recognizes the critical importance of purity and consistency for such sensitive applications. Our SMCC (CAS 64987-85-5) is manufactured under strict quality control protocols, ensuring a high purity level, typically 99% or greater, presented as a white powder. Each batch undergoes rigorous testing, and a comprehensive Certificate of Analysis (COA) is provided, giving our clients confidence in the product's quality and performance for their critical processes, whether in pharmaceuticals, diagnostics, or advanced materials research.

We offer SMCC powder in various packaging options to suit different volume requirements, including drums and bags, facilitating ease of handling and storage. Our minimum order quantity is flexible, designed to support both R&D projects and larger-scale production needs. We accept various payment terms, including TT and LC, making transactions convenient for our global clientele. Our logistics network is optimized for fast and reliable shipping, with typical delivery times of 3-5 days after payment confirmation for bulk orders. Samples are also available upon request, with standard sample delivery times of 7-10 days depending on location.

As a dedicated manufacturer and reliable supplier of fine chemicals and pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality products and exceptional service. If you are looking to buy or purchase high-purity SMCC (CAS 64987-85-5) powder, we invite you to contact us. We offer competitive price options based on order quantity and specific requirements. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your SMCC needs and benefit from our product quality, technical expertise, and commitment to fast and reliable delivery.

Whether for advanced bioconjugation, ADC development, protein modification, or solid-phase immobilization, high-quality Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is essential. NINGBO INNO PHARMCHEM CO.,LTD. stands ready as your trusted supplier to meet these demands with a consistently high-quality product and a focus on customer satisfaction. Inquire today to learn more about our SMCC offering and how we can support your research and manufacturing endeavors.