NINGBO INNO PHARMCHEM CO.,LTD. is pleased to present its high-quality Teriparatide Acetate, a crucial active pharmaceutical ingredient (API) vital for the treatment of osteoporosis. Available as a fine peptide powder, this product carries the Chemical Abstracts Service (CAS) registry number 52232-67-4, signifying its unique chemical identity.

Teriparatide Acetate is the synthetic form of the first 34 amino acids of human parathyroid hormone (PTH), which represents the bioactive N-terminal region of the endogenous 84-amino acid hormone. Unlike continuous exposure to PTH, which can lead to bone resorption, intermittent administration of this 1-34 fragment has a profound anabolic effect on bone. This makes Teriparatide Acetate a cornerstone in the therapeutic arsenal against severe osteoporosis.

The mechanism of action is complex and involves stimulating osteoblast activity. Teriparatide Acetate binds to PTH-I receptors on the surface of osteoblasts, bone lining cells, and bone marrow stromal stem cells. This interaction activates downstream signaling pathways, predominantly the adenylate cyclase cyclic adenosine monophosphate protein kinase A conduction pathway. The result is enhanced differentiation of mesenchymal stem cells into osteoblasts and prolonged lifespan of mature osteoblasts by inhibiting their apoptosis. This delicate balance shifts bone remodeling towards formation, leading to increased bone mineral density and improved bone microarchitecture, ultimately reducing the risk of debilitating fractures in patients with osteoporosis.

Osteoporosis is a widespread skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. It is a major global health problem, particularly affecting postmenopausal women, but also occurring in men and those on certain medications like glucocorticoids. Teriparatide Acetate is indicated for the treatment of osteoporosis in postmenopausal women and men at high risk for fracture, and for the treatment of glucocorticoid-induced osteoporosis in men and women with high fracture risk. Its ability to stimulate new bone formation offers a distinct advantage over anti-resorptive therapies which primarily slow down bone loss.

As a leading API supplier, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical importance of quality, consistency, and purity for pharmaceutical raw materials. Our Teriparatide Acetate peptide powder is manufactured under stringent quality control protocols to ensure it meets demanding pharmaceutical standards, including high purity levels, typically 99% or customized according to specific client requirements. The peptide synthesis process, whether solid-phase, liquid-phase, or a hybrid approach, is carefully controlled to yield a product free from undesirable impurities that could impact efficacy or safety.

Providing reliable access to essential APIs like Teriparatide Acetate (CAS 52232-67-4) is fundamental to supporting the global pharmaceutical industry's efforts to develop and manufacture life-changing medications. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a trusted partner for pharmaceutical companies seeking high-quality raw materials for osteoporosis treatments. Our supply chain is designed for efficiency and security, ensuring timely and safe delivery to various international destinations. We offer flexible supply quantities, catering to both research and development needs and larger commercial-scale production requirements.

The demand for effective osteoporosis therapies continues to grow as populations age. Teriparatide Acetate remains a vital option for patients with severe disease and high fracture risk, making the reliable supply of its API paramount. Pharmaceutical manufacturers require a dependable source for this complex peptide powder to ensure the continuity and quality of their finished drug products. NINGBO INNO PHARMCHEM CO.,LTD. stands ready to meet this need with our high-purity Teriparatide Acetate.

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