NINGBO INNO PHARMCHEM CO.,LTD. is pleased to announce the availability of high-purity Tris(2-carboxyethyl)phosphine Hydrochloride, commonly known as TCEP-HCl, with CAS registry number 51805-45-9. This compound is a versatile and essential chemical reagent widely used in various scientific and industrial applications.

Tris(2-carboxyethyl)phosphine Hydrochloride (TCEP-HCl) presents as a white crystalline powder. Its molecular formula is C9H16ClO6P, with a molecular weight of 286.65. Key specifications include an assay typically exceeding 98.0%. It has a characteristic melting point range of 170-180℃ and a density of 1.041 g/mL at 25 °C. The product is soluble in water, with a solubility of approximately 50 mg/mL, and its aqueous solution has a pH of 7.0 when adjusted with ammonium hydroxide. Proper storage at 2-8°C is recommended to maintain its stability and efficacy.

One of the primary applications of TCEP-HCl is its use as a water-soluble reagent for the selective reduction of disulfides. Disulfide bonds are crucial in the structure and function of many proteins and peptides, and their reduction is often necessary for analysis, modification, or synthesis. TCEP-HCl offers a mild yet effective method for breaking these bonds, making it invaluable in protein chemistry, diagnostics, and molecular biology.

A significant advantage of TCEP-HCl compared to other reducing agents like DTT (Dithiothreitol) is its superior stability, particularly under alkaline conditions and in the presence of air. This enhanced stability is especially beneficial in sensitive analytical techniques such as mass spectrometry, where the integrity of the reducing agent and the sample is paramount for obtaining reliable results. Its water solubility also simplifies reaction setup and workup in aqueous biological systems.

Beyond biological applications, TCEP-HCl can also be utilized in organic synthesis. For instance, after alkalization, this water-soluble ligand can facilitate the simple removal of lanthanide metathesis catalysts by aqueous washing of the crude reaction product. This highlights its utility in purification processes and simplifies post-reaction procedures in certain synthetic pathways.

Ensuring the quality and purity of chemical reagents is paramount for reproducibility and success in research and development, as well as manufacturing processes. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality Tris(2-carboxyethyl)phosphine Hydrochloride that meets stringent specifications. Quality is assured through rigorous testing, and relevant documentation is available to support product claims.

For those looking to procure this essential reagent, NINGBO INNO PHARMCHEM CO.,LTD. serves as a reliable supplier and manufacturer. We offer Tris(2-carboxyethyl)phosphine Hydrochloride in standard packaging sizes, such as 1kg per drum in a foil bag, with samples available upon request. To inquire about the current price, request a quote, or learn how to buy or purchase this product, prospective clients are encouraged to contact us directly. We aim to provide a seamless procurement experience with competitive pricing and dependable supply for your research and production needs.