2,4-Difluorophenylboronic acid, identified by its CAS number 144025-03-6, is a highly valuable chemical intermediate in the field of organic synthesis. This compound, typically presented as an off-white to yellow powder, plays a critical role as a versatile building block, enabling the creation of complex molecules essential across various industries, most notably pharmaceuticals.

The significance of 2,4-Difluorophenylboronic acid stems largely from its integral involvement in the Suzuki coupling reaction. This powerful palladium-catalyzed cross-coupling process allows for the efficient formation of carbon-carbon bonds between aryl or vinyl halides (or triflates) and aryl or vinyl boronic acids (or esters). The ability to introduce the 2,4-difluorophenyl moiety into target molecules through the mild and selective conditions of the Suzuki reaction makes this boronic acid a preferred reagent for chemists.

Within the pharmaceutical sector, 2,4-Difluorophenylboronic acid is a key precursor. It serves as an intermediate in the synthesis of various drug candidates and established pharmaceuticals. A notable application is its use in the production of Diflunisal, a non-steroidal anti-inflammatory drug (NSAID). The incorporation of the difluorophenyl group can impart desirable pharmacological properties, such as enhanced metabolic stability and lipophilicity, which are crucial for drug efficacy and bioavailability.

Beyond its pharmaceutical applications, 2,4-Difluorophenylboronic acid is also utilized in the synthesis of agrochemicals, specialty chemicals, and advanced materials. The unique electronic and steric properties conferred by the two fluorine atoms on the phenyl ring can influence the reactivity and properties of the final product, making this boronic acid a valuable tool for designing molecules with specific functionalities.

Ensuring the quality and consistency of 2,4-Difluorophenylboronic acid is paramount for reproducible synthetic outcomes. Specifications typically require a high assay, often exceeding 98.0%, and careful control of impurities, including water content. These quality parameters are vital for successful chemical transformations, especially in sensitive reactions like Suzuki coupling.

For researchers and manufacturers who require this essential intermediate, identifying a dependable source is crucial. When considering where to buy 2,4-Difluorophenylboronic acid, factors such as the reputation of the manufacturer for quality control and the reliability of the supplier for timely delivery are key considerations. Understanding the current market price and exploring options for bulk purchase are also important steps in securing a consistent supply chain. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality 2,4-Difluorophenylboronic acid, supporting the synthesis needs of the global chemical and pharmaceutical industries. Proper storage in a cool, dry, and well-ventilated area, with containers tightly closed, is recommended to maintain product integrity.