Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Hydrochloride Tipiracil, often referred to simply as Tipiracil hydrochloride or TPI, stands as a vital pharmaceutical raw material in the landscape of modern oncology. As a sophisticated Active Pharmaceutical Ingredient (API), it plays a crucial role in the formulation of advanced medicinal products aimed at combating cancer.
Primarily recognized as a Thymidine Phosphorylase Inhibitor (TPI), Tipiracil hydrochloride serves a critical function by preventing the rapid breakdown of co-administered nucleoside analog drugs, such as Trifluridine. This protective action is paramount in enhancing the bioavailability and efficacy of these cytotoxic agents, ensuring they reach tumor cells in sufficient concentrations to exert their therapeutic effects.
One of the most prominent applications of Hydrochloride Tipiracil is its inclusion as an active component in the promising anticancer drug candidate, TAS-102. TAS-102 is a combination therapy that pairs Trifluridine, a cytotoxic agent that works by being incorporated into DNA during synthesis and inhibiting tumor cell growth, with Tipiracil. The presence of Tipiracil in this formulation is key; it effectively inhibits thymidine phosphorylase, the enzyme responsible for degrading Trifluridine, especially after oral administration. This synergistic approach allows Trifluridine to remain active longer, maximizing its impact against rapidly dividing cancer cells.
Research highlights the potential of formulations containing Hydrochloride Tipiracil, such as TAS-102, in treating various types of cancer, including difficult-to-treat cases of stomach and colon cancer. The development and manufacturing of such critical APIs require stringent quality control and adherence to pharmaceutical standards to ensure purity, potency, and consistency for use in clinical trials and eventual commercial drug production.
As a leading manufacturer and supplier of high-quality pharmaceutical raw materials, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing premium grade Hydrochloride Tipiracil API. We understand the vital importance of sourcing reliable and consistent raw materials for the complex process of drug development and manufacturing. Our commitment to quality ensures that our API meets the rigorous requirements for use in cancer research and the preparation of finished medicines.
For pharmaceutical companies and researchers seeking a dependable source for Hydrochloride Tipiracil, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price options and seamless logistics. Whether you are looking to buy for research purposes or purchase in bulk for manufacturing, our team is ready to assist you with your specific needs. Enquire today to learn more about how we can support your advanced anticancer drug development projects with our high-quality API.
Written by NINGBO INNO PHARMCHEM CO.,LTD.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
