Metronidazole Powder, identified by CAS number 443-48-1, stands as a critically important Active Pharmaceutical Ingredient (API) and intermediate in the global healthcare landscape. As a white crystalline powder, it is recognized for its high purity, typically meeting or exceeding 99% minimum standards, essential for its efficacy and safety in various pharmaceutical formulations. Its molecular formula is C6H9N3O3, with a molecular weight of 171.15. This compound serves as the foundational raw material for numerous medications targeting a wide range of infections, underscoring its significance in modern medicine.

One of the primary functions of Metronidazole is its potent activity against anaerobic bacteria and protozoa. It operates through a unique mechanism, whereby it is reduced within susceptible organisms to form reactive nitro radical anions. These intermediates disrupt the DNA helix, causing strand breaks and ultimately leading to cell death. This targeted action makes Metronidazole particularly effective against pathogens that thrive in low-oxygen environments, distinguishing it from many other classes of antibiotics. Its broad spectrum within the anaerobic domain includes organisms such as *Bacteroides*, *Clostridium*, *Fusobacterium*, *Peptostreptococcus*, and others.

Beyond bacterial infections, Metronidazole is a cornerstone in the treatment of protozoal diseases. It is highly effective against *Trichomonas vaginalis*, responsible for trichomoniasis, a common sexually transmitted infection. Furthermore, it is the drug of choice for treating amebiasis, including intestinal amebiasis and extraintestinal forms like amoebic liver abscess and pleural amebiasis, caused by *Entamoeba histolytica*. Its utility also extends to conditions like giardiasis and infections caused by *Balantidium coli*.

The pharmacological profile of Metronidazole includes rapid absorption from the gastrointestinal tract when administered orally. It is widely distributed throughout body tissues and fluids, including the central nervous system, bone, and abscesses, which contributes to its effectiveness in treating systemic infections. Metabolism primarily occurs in the liver, producing active metabolites, and excretion is predominantly through the urine and feces. This pharmacokinetic profile supports various dosing regimens tailored to specific indications.

Metronidazole is frequently used in combination therapy, particularly for treating mixed aerobic and anaerobic infections, such as those encountered in complicated intra-abdominal or pelvic infections. Its compatibility with many other antibiotics, including penicillin derivatives, aminoglycosides, and certain cephalosporins, makes it a versatile agent in clinical practice. This combinatorial approach ensures comprehensive coverage against polymicrobial infections, improving patient outcomes.

The applications of Metronidazole Powder extend beyond human medicine. It is also widely used in veterinary medicine to treat similar bacterial and protozoal infections in animals, highlighting its broad therapeutic value across species. Ensuring the consistent high quality and purity of the raw API is paramount, as it directly impacts the safety, efficacy, and stability of the final drug product, whether for human or animal use.

Producing Metronidazole Powder requires stringent adherence to quality control standards and manufacturing processes. Testing methods like High-Performance Liquid Chromatography (HPLC) are crucial for verifying purity, potency, and the absence of impurities. Adherence to internationally recognized pharmaceutical standards such as USP and BP is essential to guarantee that the API is suitable for use in regulated pharmaceutical markets worldwide.

Proper handling and storage are also critical for maintaining the quality of Metronidazole Powder. It should be stored in a cool, dry place, away from light and moisture, to prevent degradation. Under suitable conditions, it typically boasts a shelf life of at least two years, providing flexibility in supply chain management and manufacturing scheduling for pharmaceutical companies.

Packaging plays a vital role in protecting the integrity of the API during transport and storage. Common packaging formats for Metronidazole Powder include 1kg foil bags, often consolidated into 10 bags per carton, and larger 25 kgs drums, offering options suitable for different scales of production and distribution needs. Minimum order quantities are often flexible to accommodate various customer requirements, from small-scale R&D to large-scale manufacturing.

The demand for high quality Metronidazole Powder remains steady due to its established clinical utility and effectiveness against a range of challenging infections. As a reliable pharmaceutical API manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing Metronidazole Powder that meets the highest industry standards for purity, consistency, and quality. Pharmaceutical companies globally rely on trusted partners for their raw material needs to ensure the safety and effectiveness of their finished products. Understanding the technical specifications, quality assurances, and supply chain capabilities of a supplier is crucial for procurement decisions.

For those seeking a dependable source, inquiring about the price and availability is the first step. Whether you are looking to buy for the first time or establish a long-term supply relationship, securing a consistent source of high-purity Metronidazole Powder from a reputable manufacturer is non-negotiable for maintaining production quality and regulatory compliance. Learn how to purchase this essential API efficiently and reliably to support your pharmaceutical production needs.