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NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of high-quality pharmaceutical excipients, including Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC). In this article, we focus on the essential role of HPMC as a binder in the production of pharmaceutical tablets, highlighting how it contributes to the integrity, compactibility, and overall performance of solid dosage forms.
Tablet binders are critical excipients that impart cohesion to powders, forming granules that can be compressed into tablets of sufficient mechanical strength. A good binder ensures that tablets do not crumble or fracture during manufacturing, handling, or transport. HPMC, with its excellent film-forming and adhesive properties, serves as an effective binder in both wet granulation and direct compression processes. Its ability to create strong bonds between particles is attributed to its polymeric nature and its capacity to form viscous solutions or gels.
In wet granulation, HPMC acts as a binding agent, holding the powder particles together as they are granulated. The resulting granules are more uniform in size and density, leading to improved flowability and compressibility. When dried, the HPMC film encapsulates the API and other excipients, providing a stable structure. For direct compression, specific grades of HPMC, often referred to as directly compressible (DC) grades, are engineered to possess optimal particle size, flowability, and compaction characteristics. These DC HPMC grades enable efficient tablet manufacturing without the need for granulation, thereby streamlining the production process and potentially reducing costs.
The performance of HPMC as a binder is influenced by its grade, including viscosity and particle size. At NINGBO INNO PHARMCHEM CO.,LTD., we offer a selection of Pharmaceutical Grade HPMC suitable for various tablet manufacturing techniques. Choosing the right HPMC grade can significantly improve powder flow, reduce capping and lamination defects, and ensure that tablets possess the required hardness and disintegration times. By leveraging the binding capabilities of HPMC, pharmaceutical companies can achieve consistent tablet quality, optimize manufacturing efficiency, and ultimately deliver safe and effective medications to patients.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
