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Hydantoin (CAS 461-72-3): A Versatile Chemical for Modern Industries

Hydantoin, formally known as Imidazolidine-2,4-dione with the CAS number 461-72-3, stands as a pivotal heterocyclic organic compound. Its unique five-membered ring structure, incorporating nitrogen and oxygen atoms, grants it exceptional versatility and makes it an indispensable intermediate across a multitude of industries. With a molecular formula of C3H4N2O2 and a molecular weight of 100.08 g/mol, this compound is supplied typically as a fine, white to light yellow powder, exhibiting high purity of 98% minimum.


Known for its stability under normal temperatures and pressures, Hydantoin possesses a melting point around 218-220 °C, making it a reliable substance for various chemical processes. Its physical properties, including a density of approximately 1.356 g/cm3, underscore its suitability for demanding applications where consistency and purity are paramount. Proper storage in a cool, dry, and well-ventilated area, away from incompatible substances, ensures its long-term integrity.


The historical journey of Hydantoin dates back to its initial isolation by Adolf von Baeyer in 1861, derived from uric acid. Since then, various synthesis methods have been developed, including the renowned Urech hydantoin synthesis and the Bucherer–Bergs reaction, typically involving the condensation of cyanohydrins with ammonium carbonate or amino acids with cyanates. These established synthetic pathways ensure a consistent and high-quality supply of Hydantoin, meeting the rigorous demands of modern manufacturing.


The applications of Hydantoin are remarkably diverse, touching upon critical sectors:

  • Pharmaceutical Industry: Hydantoin derivatives form a significant class of medicinally important compounds. They are widely recognized for their anticonvulsant properties, with drugs like phenytoin and fosphenytoin being prominent examples in the treatment of seizure disorders. Another derivative, dantrolene, serves as an effective muscle relaxant. This showcases Hydantoin's foundational role in developing vital therapeutic agents.
  • Amino Acid Synthesis: One of Hydantoin's most crucial roles is its application in the industrial synthesis of various amino acids. Through hydrolysis, Hydantoin can be converted into essential building blocks like glycine, and it is a key intermediate in the large-scale production of methionine, a vital amino acid used in animal feed and other nutritional applications.
  • Agrochemicals and Pesticides: Certain Hydantoin derivatives are incorporated into agrochemical formulations. For instance, imiprothrin, a pyrethroid insecticide, and iprodione, a widely used fungicide, both leverage the unique chemical structure of the Hydantoin moiety, contributing to agricultural pest and disease control.
  • Disinfectants and Biocides: N-halogenated Hydantoin derivatives, such as bromochlorodimethylhydantoin (BCDMH) and dichlorodimethylhydantoin (DCDMH), are powerful chlorinating and brominating agents. These compounds are extensively utilized as disinfectants, sanitizers, and biocides in water treatment, swimming pools, and various industrial settings, owing to their effective antimicrobial properties.
  • Organic Synthesis and Photosensitive Materials: Beyond these major applications, Hydantoin serves as a fundamental organic synthetic raw material for creating a wide array of specialized chemicals. It also finds use in the development of photosensitive materials, further expanding its industrial footprint.

For industries seeking a reliable manufacturer and supplier of high-purity Hydantoin (CAS 461-72-3), ensuring stringent quality control and competitive price is paramount. Those looking to buy or purchase this essential chemical intermediate can benefit from direct sourcing, guaranteeing product integrity and efficient delivery. We are committed to providing top-tier Hydantoin for your specialized industrial needs, supporting innovation and excellence across global markets.

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