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The intricate dance of protein ubiquitination and deubiquitination is a cornerstone of cellular regulation, influencing everything from protein degradation to cell cycle progression. Within this system, deubiquitinating enzymes (DUBs) like Ubiquitin C-terminal Hydrolase L3 (UCH-L3) are crucial for reversing ubiquitination, thereby maintaining protein homeostasis. Aberrant UCH-L3 activity has been implicated in various pathological conditions, making it a compelling target for scientific inquiry and therapeutic development. This is where high-quality chemical inhibitors play a pivotal role.
4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione, or TCID, stands out as a potent and highly selective inhibitor of UCH-L3. With an established IC50 of 0.6 µM and a notable selectivity advantage over UCH-L1 (over 125-fold), TCID offers researchers a precise tool to investigate the specific functions of UCH-L3. Its cell-permeable nature allows for intracellular delivery, enabling direct observation of its impact on cellular processes. For researchers seeking to buy TCID, understanding these properties is key to ensuring experimental success.
As a trusted TCID supplier, we understand the critical need for reliable research chemicals. Companies that specialize in synthesizing and distributing fine chemicals, particularly those from regions like China, are often excellent sources for high-purity compounds like TCID. These manufacturers adhere to strict quality control standards, ensuring that the product you receive meets the required specifications for your research. When procuring TCID, inquire about batch-specific analytical data to confirm purity and identity.
The scientific community widely utilizes TCID to explore the multifaceted roles of UCH-L3. Studies have employed TCID to dissect the ubiquitination of various cellular targets, shedding light on pathways involved in neurodegeneration, pain, and other cellular dysfunctions. By inhibiting UCH-L3, researchers can effectively probe the consequences of disrupted ubiquitin recycling. For laboratories requiring consistent and high-quality reagents, identifying a dependable TCID manufacturer that offers competitive pricing, especially for bulk orders, is essential for supporting ongoing research projects and advancing our understanding of cellular mechanisms.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
