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Iodobenzene, a fundamental organoiodine compound with the CAS number 591-50-4, is a cornerstone in organic synthesis due to its unique reactivity and versatility. As a derivative of benzene where one hydrogen atom is replaced by an iodine atom, its chemical formula is C6H5I. This compound is a colorless liquid that can appear yellowish with age, especially when exposed to light, highlighting the need for proper storage. For professionals in chemistry and related industries, understanding its synthesis and applications is crucial when considering its procurement.
Synthesis of Iodobenzene
The primary method for synthesizing Iodobenzene in the laboratory and on an industrial scale involves the diazotization of aniline followed by reaction with potassium iodide. This process begins with treating aniline with nitrous acid (generated in situ from sodium nitrite and a strong acid like hydrochloric acid) at low temperatures to form a diazonium salt. Subsequently, the diazonium salt is reacted with potassium iodide, which displaces the diazonium group and introduces the iodine atom, releasing nitrogen gas. This method is efficient and allows for the production of high-purity Iodobenzene, often exceeding 99.0%.
Key Chemical Properties and Reactivity
Iodobenzene exhibits a melting point of approximately -29 °C and a boiling point of around 188 °C. Its density is about 1.823 g/mL at 25 °C. The most significant chemical property driving its utility is the relatively weak carbon-iodine bond. This makes Iodobenzene more reactive than its chloro- or bromo- counterparts in nucleophilic substitution and coupling reactions. It readily reacts with magnesium to form phenylmagnesium iodide, a Grignard reagent vital for carbon-carbon bond formation. Furthermore, it serves as an excellent substrate for various transition-metal-catalyzed cross-coupling reactions, including:
Applications of Iodobenzene
The versatility of Iodobenzene translates into a broad spectrum of applications:
Sourcing Iodobenzene
For companies looking to buy Iodobenzene, particularly in bulk, partnering with established China manufacturers and suppliers is often the most strategic approach. These suppliers can provide high-purity Iodobenzene at competitive Iodobenzene prices, backed by robust quality control and reliable logistics. When evaluating potential partners, consider their adherence to purity standards (e.g., ≥99.0%), their production capacity, and their responsiveness to inquiries. Ensuring a stable supply of this essential intermediate is critical for uninterrupted research and production.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
