In the vast and intricate world of chemical synthesis, certain intermediates play pivotal roles, enabling the creation of a wide array of complex and valuable compounds. 5-Methoxyindole-3-acetonitrile, identified by its CAS number 2436-17-1, is one such critical chemical intermediate. Its unique structural attributes and reactivity make it indispensable for various applications, particularly within the pharmaceutical and fine chemical sectors. For researchers and formulators seeking to buy this compound, understanding its profile is key to successful application.

Chemical Identity and Properties

5-Methoxyindole-3-acetonitrile is characterized by its chemical structure, which features an indole ring system substituted with a methoxy group at the 5-position and an acetonitrile group at the 3-position. Its molecular formula is C11H10N2O, with a molecular weight of 186.21 g/mol. Typically presented as a white to off-white powder, it has a melting point range of 65-69°C. This compound is a vital building block due to the inherent reactivity of both the indole nucleus and the nitrile functional group, allowing for a broad spectrum of chemical transformations.

Applications and Significance

The primary value of 5-Methoxyindole-3-acetonitrile (CAS 2436-17-1) lies in its utility as a precursor and intermediate in synthetic chemistry. Its notable applications include:

• Pharmaceutical Synthesis: It is a crucial starting material in the synthesis of various active pharmaceutical ingredients (APIs). Specifically, it is used to create indole-N-acetic acid derivatives that are explored as aldose reductase inhibitors, compounds potentially beneficial in managing diabetic complications. The consistent availability of high-purity material from reliable manufacturers is essential for drug development.
• Research and Development: As a research chemical, it enables scientists to explore novel synthetic pathways and develop new classes of compounds. Its predictable reactivity makes it a staple in organic synthesis laboratories.
• Development of Bioactive Molecules: The indole structure is a core component in many biologically active compounds. 5-Methoxyindole-3-acetonitrile facilitates the synthesis of molecules with potential melatoninergic activity, contributing to research in sleep regulation and related fields.

Procurement and Supply Chain Considerations

When seeking to purchase 5-Methoxyindole-3-acetonitrile, buyers prioritize purity (commonly 98%) and a reliable supply chain. Manufacturers based in China are significant suppliers, offering competitive pricing and scalable production. It is advisable for procurement managers to engage directly with manufacturers to obtain quotes, verify product specifications through Certificates of Analysis (CoA), and ensure consistent quality for their ongoing projects.

Conclusion

5-Methoxyindole-3-acetonitrile (CAS 2436-17-1) is a fundamental intermediate with broad applications, particularly in the development of pharmaceuticals. Its consistent demand highlights its importance in modern organic synthesis. By understanding its properties and engaging with established suppliers for procurement, industries can effectively leverage this versatile chemical intermediate to drive innovation and product development.