In the expansive landscape of pharmaceutical synthesis, certain chemical intermediates stand out for their pivotal roles in the creation of vital therapeutic agents. Among these, 5-bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-4-hydroxy-6-methylpyrimidin-2(1H)-one, commonly identified by its CAS Registry Number 830346-48-0, is a compound of significant importance. This versatile pyrimidine derivative is indispensable as a key building block in the synthesis of Elagolix, a modern medication used in the treatment of endometriosis.

Manufactured by NINGBO INNO PHARMCHEM CO.,LTD., this chemical exhibits a precise and consistent profile. It appears as a white to off-white solid, indicating its high purity. Its molecular formula, C13H9BrF4N2O2, and molecular weight of 381.12, reflect its complex yet stable structure. Our stringent quality control measures ensure that each batch meets exacting standards, with an assay typically ranging from 98.0% to 102.0%. Critical parameters such as water content (≤0.5%), largest impurity (≤0.5%), and total impurities (≤1.5%) are meticulously monitored and consistently well within specified limits, confirming its suitability for sensitive pharmaceutical applications.

The primary application of 5-bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-4-hydroxy-6-methylpyrimidin-2(1H)-one lies in its role as a precursor to Elagolix. Elagolix is a potent gonadotropin-releasing hormone (GnRH) antagonist, a class of drugs that plays a crucial role in managing conditions like endometriosis by modulating hormonal pathways. Beyond its specific use in Elagolix synthesis, this chemical also finds broad utility in general organic synthesis and various laboratory research and development processes. Its unique chemical reactivity, influenced by the presence of both bromine and trifluoromethyl groups, makes it a valuable compound for developing new chemical entities and exploring novel synthetic routes.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality chemical intermediates that support advancements in the pharmaceutical industry. Our product, 5-bromo-1-(2-fluoro-6-(trifluoromethyl)benzyl)-4-hydroxy-6-methylpyrimidin-2(1H)-one, adheres to rigorous internal standards, ensuring exceptional consistency and performance. We conduct comprehensive analyses including Infrared (IR) spectroscopy for identification and precise assays to verify purity. The physico-chemical properties, such as a predicted density of 1.684±0.06 g/cm3 and a melting point exceeding 230°C (decomposition), further attest to its robust characteristics. For optimal preservation, the compound should be stored sealed in a dry environment at room temperature, maintaining its integrity over time. Its solubility is characterized as slight in solvents like Chloroform (when heated), DMSO, and Methanol.

As a reliable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical need for dependable raw materials in the chemical and pharmaceutical sectors. We invite inquiries from partners worldwide seeking to buy or purchase this essential intermediate. For detailed specifications, competitive price information, and to discuss your supply requirements, please contact us. Our commitment is to facilitate your research and production with a consistent supply of high-purity chemicals, ensuring your projects proceed with confidence and efficiency.