(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid, identified by CAS number 1012341-50-2, stands as a pivotal pharmaceutical intermediate in the synthesis of vital medications. This compound, also known by synonyms such as AHU84, AHU, and various LCZ696 intermediates, plays an indispensable role in the production of Sacubitril, a key component in modern cardiovascular therapy. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of this high-quality chemical, ensuring reliability and purity for pharmaceutical applications.

The chemical structure of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is defined by its Molecular Formula C23H29NO4 and a Molecular Weight of 383.48. Its physical characteristics include an appearance as a white or off-white powder. Key physical and chemical properties underline its stability and utility: it boasts a melting point in the range of 145-147°C, a boiling point estimated at 582.6±50.0 °C at 760 mmHg, and a flash point of 306.2±30.1 °C. The compound exhibits a density of approximately 1.1 g/cm3 and a refractive index of 1.546. Solubility tests indicate it is slightly soluble in solvents such as Chloroform, DMSO, and Methanol, making it versatile for various reaction conditions.

The primary application of this compound is its crucial role as an intermediate for Sacubitril. Sacubitril, a potent neprilysin inhibitor, is primarily used in combination with valsartan to form a synergistic medication, notably for patients suffering from chronic heart failure with reduced ejection fraction (NYHA class II-IV). This combination therapy has revolutionized the management of heart failure by significantly reducing the risk of cardiovascular mortality and hospitalizations. The precise stereochemistry of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is critical for ensuring the efficacy and safety of the final pharmaceutical product, highlighting the demand for high-purity raw materials.

At NINGBO INNO PHARMCHEM CO.,LTD., stringent quality control measures are implemented to ensure the superior quality of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid. Our specifications guarantee a purity of greater than 98%, with single impurity levels maintained at 0.5% maximum, demonstrating our commitment to excellence. For optimal preservation, the product is recommended to be stored in a well-closed container at low temperature, ideally between 2-8°C, and protected from moisture, heat, and light. Packaging is typically in 25kg cardboard drums, with options available for customized requirements to meet specific customer needs.

The synthesis of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid involves advanced chemical processes, often utilizing chiral catalysts in hydrogenation reactions to achieve the desired stereoisomeric purity and high yields. This complex synthesis underscores the technical expertise required for its production, making the selection of a reputable manufacturer and supplier paramount for pharmaceutical companies. NINGBO INNO PHARMCHEM CO.,LTD. prides itself on its robust manufacturing capabilities and efficient supply chain, positioned to serve the global pharmaceutical industry.

For those looking to buy or purchase this essential Sacubitril intermediate, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price options and reliable delivery. As a trusted supplier and manufacturer, we are committed to supporting your pharmaceutical development and production needs with high-quality chemical building blocks. We invite inquiries from serious buyers seeking a consistent and quality source for (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid to facilitate their advanced pharmaceutical syntheses. Our aim is to be your preferred partner in pharmaceutical raw materials, ensuring your operations run smoothly with superior product quality.