In the realm of synthetic organic chemistry, intermediates that offer both structural complexity and versatile reactivity are highly prized. 5-Bromopyridine-3-sulfonyl Chloride, identified by CAS number 65001-21-0, is one such compound that has garnered significant attention due to its utility in crafting sophisticated molecules. As a leading manufacturer and supplier of high-quality chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is pleased to detail the key properties and diverse applications of this essential compound.

Chemical Identity and Physical Properties

5-Bromopyridine-3-sulfonyl Chloride is a member of the heterocyclic sulfonyl halide family. Its molecular formula is C5H3BrClNO2S, with a molecular weight of approximately 256.50 g/mol. Typically, this compound presents as a white solid, a physical state confirmed by its melting point, which generally falls within the range of 60-62.5°C. This solid form offers ease of handling and storage, a practical consideration for both laboratory and industrial settings. Its purity, often specified at 95% or higher, is a testament to the quality control measures implemented by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD.

Reactivity and Synthetic Utility

The synthetic power of 5-Bromopyridine-3-sulfonyl Chloride stems from its dual functionality:

• Sulfonyl Chloride Group (-SO2Cl): This group is highly electrophilic and readily reacts with nucleophiles. Its primary role is in the formation of sulfonamides through reaction with amines, and sulfonate esters through reaction with alcohols or phenols. These linkages are fundamental in many biologically active molecules.
• Bromine Atom (-Br): The bromine substituent on the pyridine ring provides a strategic handle for further chemical modifications. It is particularly amenable to palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, or Buchwald-Hartwig couplings. These reactions enable the facile introduction of carbon-carbon and carbon-nitrogen bonds, allowing for the assembly of complex organic frameworks.

Key Applications Across Industries

The unique combination of properties makes 5-Bromopyridine-3-sulfonyl Chloride a sought-after intermediate in several key industries:

• Pharmaceutical Intermediates: This is perhaps its most significant application. The compound serves as a crucial building block in the synthesis of numerous drug candidates and Active Pharmaceutical Ingredients (APIs). Researchers leverage its structure to create compounds with desired pharmacological activities. For pharmaceutical companies looking to buy 5-Bromopyridine-3-sulfonyl Chloride, ensuring a reliable and high-purity source is paramount.
• Agrochemical Development: Similar to pharmaceuticals, the synthesis of new pesticides, herbicides, and fungicides often requires complex heterocyclic structures. This sulfonyl chloride can be an integral part of developing next-generation crop protection agents.
• Fine Chemical Synthesis: Beyond pharmaceuticals and agrochemicals, it finds use in the synthesis of various other fine chemicals where specific pyridine-based structures with sulfonyl functionalities are required.
• Research and Development: In academic and industrial research laboratories, it is a valuable reagent for exploring new synthetic methodologies and developing novel chemical entities.

When considering the price and availability of such a specialized chemical, NINGBO INNO PHARMCHEM CO.,LTD. acts as a reliable supplier in China, offering competitive pricing and consistent quality. We encourage all researchers and procurement specialists to reach out for detailed quotes and product information to facilitate their synthetic endeavors.

The strategic importance of 5-Bromopyridine-3-sulfonyl Chloride in modern organic synthesis underscores its value. Its dual reactivity ensures its continued relevance in the development of cutting-edge pharmaceuticals and fine chemicals.