In the dynamic world of pharmaceuticals and biotechnology, the quality of raw materials is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is proud to present its premium-grade Kolliphor P 188, also widely known as Poloxamer 188 or Lutrol F 68. This exceptional nonionic triblock copolymer, composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene, stands as a cornerstone excipient due to its remarkable amphiphilic properties and versatile applications across various industries, particularly in sensitive biological and pharmaceutical formulations.

Kolliphor P 188's unique molecular structure grants it potent surfactant properties, making it invaluable for enhancing the water solubility of hydrophobic substances and improving the miscibility of disparate compounds. A distinctive characteristic is its temperature-dependent self-assembling and thermo-gelling behavior. At lower temperatures and concentrations, individual block copolymers exist freely in solution. However, as temperature or concentration increases, these unimers aggregate to form micelles, with the hydrophobic polyoxypropylene core shielded by hydrophilic polyoxyethylene shells. This reversible transition from liquid to gel at higher temperatures is a crucial feature for many advanced formulations.

The applications of Kolliphor P 188 are extensive and critical. In the pharmaceutical industry, it serves as an indispensable component for emulsifying, thickening, coating, solubilizing, dispersing, and defoaming. Its utility extends significantly into drug delivery systems, where it has shown promise in sensitizing drug-resistant cancers to chemotherapy. Furthermore, Kolliphor P 188 plays a vital role in protecting proteinaceous formulations from aggregation, addressing challenges often associated with other surfactants like polysorbates and their hydrolysis issues. For bioprocess applications, particularly in mammalian cell culture, it acts as a superior cell cushioning agent, mitigating shear stress in bioreactors and ensuring optimal cell viability and productivity. Beyond these, its benefits are recognized in materials science for synthesizing mesoporous materials and in colloidal science as a steric stabilizer to prevent coalescence and reduce aggregation.

At NINGBO INNO PHARMCHEM CO.,LTD., we understand that consistency and purity are non-negotiable. Our Kolliphor P 188 is manufactured under stringent quality controls, ensuring high purity and consistent performance that minimizes manufacturing risks for our partners. While Poloxamer 188 is generally recognized for its robust chemical stability, especially in solid states, its behavior in liquid formulations can be influenced by specific buffer conditions and oxidative stresses. Extensive research indicates that factors like pH, metal ions, and even temperature fluctuations can impact its degradation profile. However, choosing a high-quality supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures that the product you receive meets rigorous standards, providing reliability and peace of mind in your processes.

For manufacturers seeking a dependable supplier of high-quality Kolliphor P 188, NINGBO INNO PHARMCHEM CO.,LTD. is your trusted partner. We offer this versatile excipient, ensuring competitive price and superior product quality. If you are looking to buy or purchase Kolliphor P 188, Poloxamer 188, or Lutrol F 68, contact us to discuss your specific requirements. Our commitment to excellence as a leading manufacturer guarantees that you receive a product optimized for performance and reliability in your most critical applications.