L-Asparaginase, an indispensable enzyme with the CAS number 9015-68-3, stands as a cornerstone in both the pharmaceutical and food industries. NINGBO INNO PHARMCHEM CO.,LTD. prides itself on being a premier manufacturer and supplier of high-quality L-Asparaginase powder, distinguished by its exceptional purity and profound efficacy across diverse applications.

In the pharmaceutical sector, L-Asparaginase is a critical therapeutic agent, particularly in the management of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). The enzyme's mechanism of action hinges on a fundamental metabolic difference between healthy cells and certain cancer cells. Malignant cells, especially those in leukemia, exhibit a unique dependency on external sources of L-Asparagine, an amino acid vital for protein synthesis and proliferation. Unlike normal cells, these cancerous counterparts often lack the inherent enzymatic machinery to produce sufficient asparagine on their own. L-Asparaginase effectively exploits this vulnerability by catalyzing the hydrolysis of L-Asparagine into aspartic acid and ammonia, thereby depleting this essential nutrient from the bloodstream. This targeted nutritional deprivation halts protein synthesis in the cancer cells, ultimately triggering their programmed cell death, or apoptosis. This precise mode of action makes L-Asparaginase an integral part of modern chemotherapy protocols, significantly contributing to improved remission rates and survival outcomes for patients globally.

Beyond its well-established role in oncology, contemporary research continues to unveil deeper insights into L-Asparaginase's cellular mechanisms. Recent studies highlight its capacity to induce endoplasmic reticulum (ER) Ca2+ release by specifically interacting with cellular receptors such as µ-opioid receptor 1 (µ-OR1) and protease-activated receptor 2 (PAR2). This intricate signaling pathway leads to a lethal elevation of intracellular calcium, contributing further to the demise of leukemic cells. While demonstrating immense therapeutic potential, it is important to note that L-Asparaginase therapy, like other powerful medications, requires careful medical supervision due to potential side effects. These can include allergic reactions, which range from mild skin rashes to more severe anaphylaxis, as well as pancreatitis, blood clotting disorders, liver enzyme abnormalities, and gastrointestinal upset. Rigorous patient monitoring is essential to mitigate these effects and ensure optimal treatment safety.

Parallel to its life-saving medical applications, L-Asparaginase is gaining significant traction in the food industry as an innovative solution for enhancing food safety. A prevalent concern during the high-temperature processing of starchy foods – such as baking bread, crackers, and cookies, or frying French fries and potato chips – is the formation of acrylamide. This compound, classified as a probable human carcinogen, forms through the Maillard reaction between asparagine and reducing sugars at temperatures exceeding 120°C. By strategically incorporating L-Asparaginase into food production, the enzyme effectively hydrolyzes free asparagine present in raw materials, drastically reducing its availability as a precursor for acrylamide formation. This enzymatic intervention allows food manufacturers to produce safer food products with significantly lower acrylamide levels, all while preserving the desirable taste, texture, and appearance of the final product.

The L-Asparaginase offered by NINGBO INNO PHARMCHEM CO.,LTD. is presented as a high-purity, light brown-yellow to white powder, meticulously produced to meet stringent quality standards. Our product typically boasts an impressive purity of 99% and an activity of 3000u/G, ensuring consistent performance. It is designed for broad applicability within the food processing sector, performing optimally within a wide temperature range of 10°C to 60°C and a pH range of 4.0 to 11.0. For flour-based products, a recommended dosage of 20-500g per ton of flour facilitates effective acrylamide reduction, making it a highly efficient ingredient for improving food safety profiles.

As a dedicated L-Asparaginase manufacturer and L-Asparaginase supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to excellence and reliability. We ensure that our production processes adhere to rigorous quality control measures, offering products that meet or exceed international specifications. For those seeking to buy L-Asparaginase or explore L-Asparaginase price options, our expert team is ready to provide comprehensive support and competitive offerings. We aim to be your trusted partner for all L-Asparaginase purchase needs, supporting advancements in both healthcare and food safety worldwide.