Introduction to Lidocaine Hydrochloride

Lidocaine Hydrochloride, often referred to as Lidocaine HCl, is a cornerstone of modern medicine, widely recognized for its efficacy as a local anesthetic and its role as a Class-Ib antiarrhythmic agent. Chemically designated as 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride, this compound is a versatile and indispensable raw material in the pharmaceutical industry. At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in producing high-purity Lidocaine HCl powder, a white to off-white crystalline solid that is highly soluble in water and meets the stringent quality requirements of the United States Pharmacopeia (USP) and British Pharmacopoeia (BP). With the CAS number 73-78-9, our product serves as a critical active pharmaceutical ingredient (API) for various medical formulations.

Mechanism of Action

The primary function of Lidocaine HCl is to reversibly block nerve signal transmission, thereby inducing temporary numbness and pain relief in a localized area. It achieves this by stabilizing the neuronal membrane. The core mechanism involves blocking the fast voltage-gated sodium (Na+) channels in the nerve cell membrane. By binding to the sodium channels in their open state from within the cell, Lidocaine HCl prevents the influx of sodium ions that is necessary for the initiation and conduction of nerve impulses. This action effectively stops the pain signal from reaching the brain, resulting in local anesthesia without causing a loss of consciousness. Its rapid onset and intermediate duration of action make it a preferred choice for a multitude of procedures.

Diverse Pharmaceutical Applications

The versatility of Lidocaine HCl powder allows for its incorporation into a wide array of dosage forms, each tailored for specific medical applications.

1. Topical and Surface Anesthesia: As a raw material, Lidocaine HCl is formulated into creams, ointments, gels, sprays, and patches. These preparations are used to numb the skin before minor surgical procedures like needle punctures, intravenous cannulation, or dermatological treatments. They are also effective in providing symptomatic relief from pain and itching associated with sunburn, insect bites, and minor skin irritations.

2. Infiltration and Nerve Block Anesthesia: Sterile solutions of Lidocaine HCl are used for infiltration anesthesia, where the anesthetic is injected directly into the tissue to numb a specific area. It is also a staple in regional nerve blocks, such as brachial plexus or intercostal blocks, providing anesthesia to an entire limb or region of the body. In dentistry, it is one of the most commonly used anesthetics for pain control during various procedures.

3. Epidural and Spinal Anesthesia: In major surgical procedures, Lidocaine HCl is administered into the epidural space of the spinal column. This provides profound anesthesia over large areas of the body, such as the abdomen, pelvis, or lower limbs, making it essential for surgeries and pain management during childbirth.

4. Cardiac Arrhythmia Treatment: Beyond its anesthetic properties, Lidocaine HCl is a critical drug in cardiology. Administered intravenously, it is used for the acute management of life-threatening ventricular arrhythmias, particularly those occurring after a myocardial infarction or during cardiac surgery. It works by decreasing the electrical excitability of the heart's ventricles.

Commitment to Quality and Purity

The efficacy and safety of any pharmaceutical formulation depend entirely on the quality of its raw materials. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier dedicated to providing Lidocaine HCl powder of the highest purity, consistently meeting and exceeding USP and BP standards. Our state-of-the-art manufacturing facilities operate under strict Good Manufacturing Practices (GMP), ensuring that every batch of our product is reliable, consistent, and free from impurities. The appearance of our product is a white or almost white crystalline powder with a purity level of over 99%.

We employ advanced analytical techniques to verify the identity, strength, quality, and purity of our Lidocaine HCl. This rigorous quality control process guarantees that our clients receive a premium-grade material suitable for the most sensitive pharmaceutical applications. Our commitment to excellence ensures that formulators and researchers can confidently use our product to develop safe and effective medical treatments.

Sourcing High-Grade Lidocaine HCl

For pharmaceutical companies and research institutions looking to buy or purchase Lidocaine HCl powder, selecting a reliable partner is paramount. NINGBO INNO PHARMCHEM CO.,LTD. stands as a trusted global supplier and manufacturer of this essential API. We understand the critical nature of a stable and transparent supply chain. We offer competitive price points without compromising on the quality or purity that our clients depend on. Our experienced logistics team ensures secure packaging and timely global delivery to support your manufacturing and research timelines. If you are seeking to source top-tier Lidocaine HCl powder, we invite you to connect with us to learn more about our product specifications and how we can meet your specific needs.