Linaclotide is a synthetic peptide, a vital pharmaceutical ingredient recognized for its targeted action in gastrointestinal disorders. Its unique mechanism offers significant therapeutic potential, making it a key component in the development of innovative treatments. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-quality Linaclotide powder, serving the global pharmaceutical industry with a commitment to excellence and reliability.

Linaclotide functions as a guanylate cyclase-C (GC-C) agonist. Upon administration, it selectively binds to and activates GC-C receptors located on the luminal surface of the intestinal epithelium. This activation leads to an increase in intracellular and extracellular cyclic guanosine monophosphate (cGMP) concentrations. Elevated cGMP levels then stimulate the secretion of chloride and bicarbonate into the intestinal lumen, which in turn increases intestinal fluid secretion. Concurrently, it reduces the activity of pain-sensing nerves, contributing to the alleviation of abdominal pain. This dual action facilitates the softening of stools and accelerates gastrointestinal transit, providing effective relief for patients.

The primary applications of Linaclotide revolve around the management of specific chronic constipation-related conditions. It is widely used in formulations designed for adults suffering from Irritable Bowel Syndrome with Constipation (IBS-C), a disorder characterized by recurrent abdominal pain and constipation. Additionally, it is a crucial active pharmaceutical ingredient for treating Chronic Idiopathic Constipation (CIC) in adults, where the cause of constipation is unknown. Recent advancements also indicate its utility in addressing Functional Constipation (FC) in pediatric patients aged 6 to 17 years, expanding its therapeutic reach. These applications highlight Linaclotide's critical role in improving the quality of life for individuals grappling with these persistent gastrointestinal issues.

At NINGBO INNO PHARMCHEM CO.,LTD., we specialize in the production and supply of premium Linaclotide powder (CAS 851199-59-2). Our product adheres to stringent quality standards, including CHP, USP, IP, pH.Int., and Bp grades, ensuring high purity and consistent performance for pharmaceutical manufacturing. We understand the critical need for a reliable supply chain in the pharmaceutical sector. Our state-of-the-art manufacturing facilities and rigorous quality control processes guarantee a stable and high-quality raw material, providing a solid foundation for your finished drug products. We offer Linaclotide in white powder form, packaged securely to maintain its integrity during storage and transport. It is recommended to store the powder in a cool, dry place, in its original tightly closed container, with the desiccant packet intact, to protect it from moisture.

While NINGBO INNO PHARMCHEM CO.,LTD. supplies Linaclotide as a raw material, it is crucial for our clients, as pharmaceutical manufacturers, to be aware of the safety profile associated with the final drug product. The most common side effect observed in clinical use is diarrhea, which can sometimes be severe. Other reported side effects include abdominal pain, gas, and abdominal distension. Serious adverse reactions, though less common, can include severe allergic reactions and severe dehydration, particularly concerning in young children. Linaclotide is contraindicated in children under 2 years of age due to the risk of severe dehydration. It should also not be administered to patients with a known or suspected mechanical gastrointestinal obstruction. These considerations underscore the importance of thorough patient assessment and adherence to prescribed guidelines when formulating and distributing Linaclotide-based medications.

As a dedicated Linaclotide manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting pharmaceutical companies worldwide. We pride ourselves on offering a competitive price for our high-quality Linaclotide powder, facilitating efficient production for our partners. If you are looking to buy Linaclotide powder or purchase in bulk, our team is ready to provide comprehensive support, from technical specifications to logistics. We invite inquiries from pharmaceutical companies and research institutions seeking a reliable manufacturer of this essential peptide. Our goal is to contribute to the advancement of gastrointestinal health by supplying superior pharmaceutical raw materials.