Published by NINGBO INNO PHARMCHEM CO.,LTD.

Liraglutide API (Active Pharmaceutical Ingredient), identified by its CAS number 204656-20-2, stands as a cornerstone in modern pharmacological approaches to metabolic disorders. As a synthetic analog of glucagon-like peptide-1 (GLP-1), it mimics the action of the naturally occurring incretin hormone, playing a crucial role in glucose regulation and appetite control. Recognizing its significance, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality Liraglutide API to support the development and manufacturing of essential medications worldwide.

This white powder is the foundational raw material for injectable formulations used primarily in the management of Type 2 Diabetes Mellitus and chronic weight management. Its therapeutic efficacy stems from its unique mechanism of action as a potent GLP-1 receptor agonist. By binding to and activating GLP-1 receptors, Liraglutide stimulates glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon secretion, slows gastric emptying, and increases satiety. These combined effects lead to improved glycemic control and significant weight loss.

Beyond its primary indications, research and clinical experience have illuminated Liraglutide's broader potential benefits. Studies suggest protective effects on pancreatic beta cells, crucial for preserving endogenous insulin production. Furthermore, evidence indicates cardiovascular benefits, including reductions in major adverse cardiovascular events in patients with Type 2 Diabetes and established cardiovascular disease. Emerging research is also exploring its potential roles in protecting liver health and its therapeutic effects on neurological conditions such as Alzheimer's disease, underscoring the multifaceted utility of this remarkable API.

The structural design of Liraglutide is key to its sustained action. It is an acylated human GLP-1 analog produced via recombinant DNA technology, often in organisms like Saccharomyces cerevisiae. Its structure closely resembles human GLP-1 (7-37) but incorporates modifications, notably the substitution of Lysine at position 34 with Arginine and the addition of a C16 palmitoyl fatty acid side chain via a glutamate linker to Lysine at position 26. This fatty acid chain facilitates binding to albumin in the bloodstream, extending its half-life and allowing for once-daily administration, a significant advantage for patient convenience and adherence.

Ensuring the quality and purity of Liraglutide API is paramount for pharmaceutical applications. High-performance Liquid Chromatography (HPLC) is the standard method for assessing purity, consistently demonstrating levels typically exceeding 99%. Strict quality control measures are essential to monitor related peptides, residual solvents, water content, acetate levels, and bacterial endotoxins, ensuring the API meets stringent pharmacopoeial standards such as USP and BP, as well as adhering to Good Manufacturing Practice (GMP) principles. A high-quality API is critical for the safety, efficacy, and stability of the final drug product.

Reliable sourcing of Liraglutide API is crucial for pharmaceutical manufacturers. NINGBO INNO PHARMCHEM CO.,LTD. offers Liraglutide API meeting rigorous quality specifications. The product is typically supplied as a white powder, packaged securely in materials like foil bags or drums to maintain stability during transport and storage. While minimum order quantities may vary, options are available to accommodate research needs (e.g., starting from 10g) up to large-scale commercial production volumes, reflecting a production capacity designed to meet global demand.

For companies looking to buy Liraglutide API or purchase Liraglutide CAS 204656-20-2, selecting a trustworthy manufacturer and supplier is vital. Factors such as product purity, consistency between batches, regulatory documentation support, and reliable supply chain logistics are critical considerations. The price of Liraglutide API can vary depending on purity, quantity ordered, and supplier, but prioritizing quality and reliability ensures the integrity of the final pharmaceutical product.

NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated supplier and source for high-quality Liraglutide API, committed to supporting our partners in the pharmaceutical industry. We understand the importance of a consistent, high-purity raw material for developing life-changing medications for diabetes, obesity, and potentially other conditions. Our goal is to be your preferred manufacturer and supplier, offering competitive solutions for those seeking to buy this essential API in bulk or smaller quantities. Contact us to discuss your specific Liraglutide API requirements and learn more about our commitment to quality and service.