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Malate Dehydrogenase (MDH), recognized by its EC number 1.1.1.37, is a remarkable enzyme that facilitates a crucial reversible reaction in cellular metabolism: the oxidation of L-malate to oxaloacetate, coupled with the reduction of NAD+ to NADH. This enzymatic activity is fundamental to both the energy-producing citric acid cycle and the glucose-synthesizing pathway of gluconeogenesis. For professionals in the B2B chemical and pharmaceutical sectors, understanding the precise mechanism and diverse industrial applications of MDH is key to leveraging its potential.
The catalytic mechanism of Malate Dehydrogenase involves a series of steps at its active site, where malate and its coenzyme NAD+ bind. Key amino acid residues, such as histidine and arginine, play critical roles in proton and hydride transfer, enabling the efficient conversion of malate to oxaloacetate. This catalytic prowess makes MDH an invaluable tool in various industrial settings. For instance, its role in the citric acid cycle means it's studied extensively in metabolic engineering and research aimed at optimizing energy production in cells.
Industrially, MDH finds significant application in the development of diagnostic kits. It is often used as a reagent in assays that measure the activity of other enzymes like aspartate aminotransferase (AST), a common biomarker for liver function. The reliability and accuracy of these diagnostic tests depend heavily on the quality of the MDH used. Therefore, sourcing high-purity Malate Dehydrogenase from reputable suppliers is paramount. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier dedicated to providing precisely this high-grade enzyme, ensuring that our clients can buy Malate Dehydrogenase with confidence for their critical applications.
When you need to purchase Malate Dehydrogenase (CAS 9001-64-3) for your research or manufacturing needs, consider the expertise and quality assurance provided by NINGBO INNO PHARMCHEM. We ensure our product meets the highest standards, supporting your advancements in biochemistry and diagnostics.
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A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
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