The intricate process of synthesizing oligonucleotides, the building blocks of DNA and RNA, demands precise and reliable chemical reagents. Among these, 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole, commonly known as MSNT, has emerged as a highly effective condensing reagent, playing a crucial role in various synthesis strategies, particularly the phosphotriester method. As a leading manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with high-quality MSNT to facilitate their groundbreaking work.

Oligonucleotides are fundamental to advancements in molecular biology, genetic engineering, diagnostics, and therapeutics. Their synthesis involves the sequential coupling of nucleotide monomers, a process that requires reagents capable of forming phosphodiester or phosphotriester bonds efficiently and with minimal side reactions. MSNT excels in this capacity, acting as a potent condensing agent that activates the phosphate group for nucleophilic attack by the alcohol group of the next nucleotide. This reliable coupling action is key to achieving high yields and purity in the final oligonucleotide product.

The effectiveness of MSNT as an oligonucleotide synthesis reagent stems from its unique chemical structure. The presence of the mesitylene sulfonyl group and the nitro group on the triazole ring confers specific reactivity and stability. With a molecular formula of C11H12N4O4S and a molecular weight of 296.30 g/mol, MSNT typically presents as an off-white to pale yellow crystalline powder, with purity levels often exceeding 98.0% as verified by HPLC. This high level of purity is paramount for sensitive synthesis procedures, ensuring that impurities do not interfere with the delicate coupling reactions or compromise the integrity of the synthesized oligonucleotide.

For researchers and laboratories seeking to purchase MSNT, sourcing from a reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. is essential. As a dedicated 1-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazole supplier in China, we ensure that our product meets stringent quality standards. Our MSNT is manufactured with meticulous care, guaranteeing its performance in critical applications. We understand the importance of consistent quality for reproducible research, and our commitment to excellence is reflected in every batch we produce. Whether you are involved in basic research, diagnostics development, or the synthesis of therapeutic oligonucleotides, our MSNT is designed to meet your needs.

The application of MSNT is not limited to just oligonucleotide synthesis; its properties also make it a valuable tool in broader organic synthesis. Its ability to promote condensation reactions makes it a versatile chemical intermediate. For those embarking on complex molecular constructions, acquiring MSNT from a trusted Chinese manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. provides access to a reliable and high-performing reagent that can significantly enhance the efficiency and success rate of their synthesis projects.