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The Mechanism of Action of Metronidazole: How it Fights Infections

Metronidazole is a powerful antimicrobial agent renowned for its efficacy against anaerobic bacteria and protozoa. Its mechanism of action is quite specific, targeting the unique biological processes of these microorganisms. At its core, metronidazole functions as a prodrug, meaning it becomes activated within the target organism. This activation process is key to its selective toxicity, minimizing harm to human cells.

The magic of metronidazole lies in its ability to disrupt the DNA of susceptible anaerobic organisms. When metronidazole enters these organisms, its nitro group is reduced in an environment of low oxygen potential, which is characteristic of anaerobes. This reduction process generates reactive intermediates, specifically nitroso radicals. These highly reactive species then interact with the organism's DNA, causing strand breaks and destabilizing its helical structure. This damage ultimately inhibits nucleic acid synthesis, leading to cell death.

This targeted approach makes metronidazole particularly effective against a range of pathogens, including those responsible for conditions like bacterial vaginosis and trichomoniasis. The ability of metronidazole to selectively target organisms in low-oxygen environments is a significant advantage. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in the pharmaceutical supply chain, providing the high-quality raw materials necessary for manufacturing metronidazole, ensuring its availability for critical treatments.

Understanding the mechanism of action of metronidazole not only highlights its scientific sophistication but also underscores the importance of correct usage. Factors such as incomplete courses of treatment or misuse can contribute to the development of resistance. Therefore, adherence to prescribed dosages and treatment durations is crucial for maintaining the efficacy of metronidazole and combating the growing challenge of antimicrobial resistance.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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