Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Understanding the precise molecular mechanisms behind senolytics is crucial for their effective development and application. At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to providing high-quality compounds like FOXO4-D-Retro-Inverso (FOXO4-DRI) that enable this deep scientific inquiry. This peptide is a prime example of targeted cellular intervention, specifically designed to induce senescent cell apoptosis.
Senescent cells, while a natural part of the aging process and cellular stress responses, can become detrimental when they accumulate. They resist normal cell death pathways, persisting in tissues and secreting pro-inflammatory factors that damage their surroundings. This creates an environment conducive to age-related diseases and tissue dysfunction.
The action of FOXO4-DRI is particularly fascinating. It is a peptide mimetic that targets the FOXO4 protein, a transcription factor involved in cellular stress response and apoptosis. Specifically, FOXO4-DRI is designed to bind to p53, a critical protein that promotes cell cycle arrest in senescent cells. By binding to p53, FOXO4-DRI disrupts the interaction between p53 and its partners, leading to the activation of apoptotic pathways within the senescent cell.
This process of senescent cell apoptosis induction is highly specific. Studies have shown that FOXO4-DRI preferentially affects senescent cells, leaving healthy, dividing cells unharmed. This selectivity is what makes it such a promising candidate for therapeutic applications in aging and related diseases, as it minimizes the risk of off-target effects.
For researchers utilizing FOXO4-DRI in life extension studies or for developing new treatments, the purity and structural integrity of the peptide are paramount. NINGBO INNO PHARMCHEM CO.,LTD. ensures that our custom peptide synthesis produces pharmaceutical grade peptides that adhere to strict quality standards, guaranteeing the reliability of the mechanism of action being investigated.
The ability to precisely engineer peptides like FOXO4-DRI to target specific cellular processes represents a significant leap forward in biotechnology. As our understanding of cellular aging deepens, such targeted interventions will play an increasingly vital role in promoting healthspan and potentially extending lifespan. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a supplier of these advanced research tools, facilitating crucial scientific progress.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
