Beyond its well-established roles in animal nutrition and pharmaceutical synthesis, Menadione Sodium Bisulfite (CAS 130-37-0) serves as a valuable tool in scientific research, particularly for investigating cellular oxidative stress. Its ability to generate reactive oxygen species (ROS) makes it a common agent for inducing controlled oxidative damage in cell cultures and biological models, allowing researchers to study disease mechanisms, cellular defense pathways, and potential therapeutic interventions. As a reliable supplier of high-purity chemicals for research, we understand the specific needs of the scientific community.

Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify these reactive intermediates or repair the resulting damage. ROS, such as superoxide anions and hydrogen peroxide, are natural byproducts of cellular metabolism, but their overproduction can lead to damage to DNA, proteins, and lipids, contributing to aging and various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.

Menadione Sodium Bisulfite is particularly effective at inducing oxidative stress due to its redox cycling properties. Once introduced into a biological system, it can undergo autoxidation, donating an electron to molecular oxygen to form a superoxide radical. This process can then continue, generating a cascade of ROS. This ability to generate ROS in a controlled manner makes it an ideal chemical for experimental studies aiming to replicate or investigate the effects of oxidative damage.

Researchers commonly use Menadione Sodium Bisulfite in vitro to treat cell lines and observe the cellular responses to oxidative insult. Studies might focus on measuring parameters like cell viability, apoptosis induction, DNA damage, lipid peroxidation, and the activation of antioxidant defense mechanisms (e.g., glutathione levels, expression of antioxidant enzymes). By observing these responses, scientists can gain insights into the specific pathways affected by oxidative stress and the potential efficacy of antioxidant compounds or other therapeutic agents.

The water-soluble nature of Menadione Sodium Bisulfite simplifies its use in cell culture media. High-purity material, with a purity of >95% (HPLC), is essential for ensuring that experimental results are accurate and reproducible, free from confounding impurities. For researchers and procurement managers in academic institutions or R&D departments, sourcing from a trusted manufacturer is paramount.

If your research involves studying oxidative stress, cellular damage, or the protective effects of antioxidants, Menadione Sodium Bisulfite is a valuable reagent to consider. We offer this compound in various quantities suitable for laboratory research, providing consistent quality and prompt delivery. We encourage researchers to inquire about our pricing for small to bulk quantities of CAS 130-37-0 and to request samples for their experimental needs. Partner with us to ensure the reliability of your research materials.