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The Synthesis Pathway of Methotrexate: A Look at Key Intermediates

Methotrexate, a cornerstone in chemotherapy and autoimmune disease treatment, relies on a sophisticated synthesis pathway that involves several key chemical intermediates. Among these, Pyrimidine-2,4,5,6-tetraamine sulfate (CAS: 5392-28-9) plays a particularly vital role. As a reputable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is deeply involved in providing the high-quality components necessary for the production of this essential drug. The synthesis of Methotrexate is a multi-step process, and the purity and availability of intermediates like Pyrimidine-2,4,5,6-tetraamine sulfate are critical for efficiency and success. Our role as a supplier is to ensure that pharmaceutical manufacturers have consistent access to this intermediate, enabling the continuous production of Methotrexate. The chemical properties of Pyrimidine-2,4,5,6-tetraamine sulfate, specifically its amine groups, are instrumental in forming the pteridine ring system that is central to Methotrexate's structure and function. The high assay (≥98.0%) of the product we supply guarantees that it can be effectively utilized in complex reaction sequences. For companies looking to source this intermediate, understanding its position within the broader synthesis pathway is crucial. NINGBO INNO PHARMCHEM CO.,LTD. not only supplies the chemical but also strives to support the pharmaceutical industry's efforts in drug manufacturing. Our commitment to quality and reliable supply chains means that research and production facilities can depend on us for their Methotrexate intermediate needs. This ensures that vital treatments remain accessible to patients who rely on them, underscoring the significance of sourcing this chemical from a trusted source like NINGBO INNO PHARMCHEM CO.,LTD.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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