Methyl 3-aminocrotonate, identified by its Chemical Abstracts Service (CAS) number 14205-39-1, stands as a pivotal chemical intermediate within the pharmaceutical industry. With a molecular formula of C5H9NO2 and a molecular weight of 115.13 g/mol, this versatile compound is instrumental in the synthesis of a range of active pharmaceutical ingredients (APIs) that address significant health concerns globally. NINGBO INNO PHARMCHEM CO.,LTD. proudly offers this high-quality compound, ensuring its critical role in advanced chemical syntheses.

Methyl 3-aminocrotonate typically presents as an off-white to light yellow crystalline powder, though some variations may appear as a yellowish semi-solid. Its high purity, generally boasting a minimum assay of 97% to 99%, is critical for its application in sensitive pharmaceutical processes. Key physical properties include a melting point ranging from 81°C to 89°C. It exhibits a boiling point of approximately 112°C at 42 mmHg and 194.1°C at standard atmospheric pressure (760 mmHg), with a flash point of 91°C. Notably, Methyl 3-aminocrotonate is insoluble in water but demonstrates excellent solubility in common organic solvents like chloroform and acetone, with solubilities exceeding 500g/L at 20°C. These well-defined specifications underscore its suitability for demanding chemical reactions.

The primary application of Methyl 3-aminocrotonate lies in its function as a crucial intermediate for the synthesis of several essential pharmaceutical compounds. It is predominantly used in the production of calcium channel blockers, a class of drugs vital for managing hypertension (high blood pressure) and certain cardiac conditions. Specifically, it serves as a key precursor for nicardipine and nitrendipine, two widely recognized medications in this therapeutic area. Beyond these, Methyl 3-aminocrotonate also plays a significant role in the synthesis of amlodipine base and amlodipine besylate, further solidifying its importance in cardiovascular pharmacotherapy. Its unique chemical structure allows for efficient and precise reactions, making it indispensable for creating these life-saving drugs. The consistent quality of this intermediate directly impacts the efficacy and safety of the final pharmaceutical products.

At NINGBO INNO PHARMCHEM CO.,LTD., our commitment to quality is paramount. We ensure that every batch of Methyl 3-aminocrotonate meets stringent purity and specification standards. Our robust quality control measures include comprehensive testing and the provision of detailed certificates of analysis and relevant reports to guarantee product integrity. Samples are readily available for clients to conduct their own evaluations, affirming our transparency and confidence in our product. We understand the critical nature of pharmaceutical intermediates and strive to be a reliable partner in the supply chain, offering consistent product quality vital for stable and efficient production processes.

Methyl 3-aminocrotonate is typically supplied in 25KG drums, ensuring safe handling and transport. Proper storage is crucial to maintain its stability and efficacy. It should be stored in a cool, dry, and well-ventilated area, with containers kept tightly closed when not in use. It is imperative to keep the compound away from incompatible substances, such as strong oxidants and acids, as well as open flames and high-temperature environments, to prevent hazardous reactions. Regarding safety, Methyl 3-aminocrotonate is classified as harmful if swallowed, and can cause skin irritation and serious eye irritation. Inhalation may cause respiratory irritation. Appropriate personal protective equipment and adherence to standard chemical handling procedures are strongly advised to ensure the safety of personnel.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being your preferred manufacturer and supplier of Methyl 3-aminocrotonate CAS 14205-39-1. Our long-standing expertise in chemical synthesis, combined with our unwavering focus on product quality and customer satisfaction, positions us as a leading source for pharmaceutical intermediates. We offer competitive price options and efficient delivery to support your production schedules. For those looking to buy or purchase this essential compound, we encourage you to reach out to our sales team for detailed quotes and comprehensive support. We are committed to fostering long-term partnerships and providing the foundational chemical components that drive innovation and success in the global pharmaceutical market.