Methyl 3-carbamimidamido-4-methylbenzoate nitrate, identified by its CAS number 1025716-99-7, is a pivotal chemical compound in the pharmaceutical industry. Also known by various synonyms such as Methyl 3-guanidino-4-methylbenzoate nitrate, this white crystalline substance boasts high purity, typically exceeding 99%. Its molecular formula, C10H14N4O5, and molecular weight of 270.24200, define its unique chemical profile. The compound's significance stems from its indispensable role as a key intermediate in the synthesis of vital pharmaceutical drugs, notably those in the Nilotinib family.

This compound is characterized by a distinct chemical structure featuring a guanidino group and a nitrate component, which collectively contribute to its stability and reactivity. While specific physical parameters like density, boiling point, melting point, flash point, and refractive index are often context-dependent, its consistent appearance as a white crystalline solid indicates high quality. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the product adheres to stringent specifications, guaranteeing a purity level of ≥99%, which is essential for pharmaceutical applications. For optimal preservation, it is crucial to store this material in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances. Packaging is typically available in 25kg cardboard drums, with options for customized requirements to meet specific customer needs.

The primary and most critical application of Methyl 3-carbamimidamido-4-methylbenzoate nitrate is its use as an intermediate in the production of Nilotinib and its related derivatives, including Nilotinib hydrochloride monohydrate (CAS 923288-90-8), Nilotinib (CAS 641571-10-0), and Nilotinib hydrochloride (CAS 923288-95-3). Nilotinib is a highly effective tyrosine kinase inhibitor, a cornerstone drug in the treatment of chronic myelogenous leukemia (CML), particularly for patients who have shown resistance to other therapies. The intermediate’s role in Nilotinib’s synthetic pathway is fundamental, facilitating the precise formation of the molecular architecture that confers Nilotinib its therapeutic efficacy. This direct link highlights the compound's profound impact on advancing life-saving medical treatments and underscores the demand for exceptionally high production standards.

The synthesis of Methyl 3-carbamimidamido-4-methylbenzoate nitrate typically involves a multi-step process. A common method begins with the reaction of 3-amino-4-methylbenzoic acid with methyl chloroformate, yielding methyl 3-amino-4-methylbenzoate. This crucial intermediate then reacts with cyanamide, leading to the formation of methyl 3-carbamimidamido-4-methylbenzoate, which is subsequently treated with nitric acid to yield the nitrate salt. Beyond its synthesis, the compound demonstrates versatile chemical reactivity. It can undergo oxidation using strong oxidizing agents like potassium permanganate or chromium trioxide, resulting in corresponding carboxylic acids. Reduction reactions can be achieved with agents such as lithium aluminum hydride or sodium borohydride, forming amines. Furthermore, nucleophilic substitution reactions allow the carbamimidamido group to be replaced by other nucleophiles like halides or alkoxides, broadening its synthetic utility.

Beyond its pivotal role in Nilotinib synthesis, Methyl 3-carbamimidamido-4-methylbenzoate nitrate holds significant potential for wider applications within the fine chemical and pharmaceutical sectors. Its guanidino functional group offers versatility in various organic synthesis pathways, suggesting its utility in the development of other therapeutic agents or specialized chemicals. Researchers continuously explore its chemical reactivity to uncover novel uses, establishing it as a compound of considerable interest for innovative developments. The mechanism of action for this compound, when studied in biological contexts, often involves its capacity to inhibit specific enzymes and proteins, thereby disrupting cellular processes. This inhibition can lead to diverse biological effects, including potential antimicrobial or anticancer activities, making it a subject of ongoing pharmacological research.

As a dedicated manufacturer and supplier of Methyl 3-carbamimidamido-4-methylbenzoate nitrate, NINGBO INNO PHARMCHEM CO.,LTD. is committed to upholding the highest standards of quality and reliability in its production processes. Our expertise ensures that this crucial pharmaceutical intermediate is produced with precision and consistency, meeting international quality benchmarks. When considering the price and availability, clients can expect competitive offerings and efficient logistics. We facilitate seamless global delivery, with robust packaging designed to protect the product's integrity during transit. For those looking to buy or purchase high-quality Methyl 3-carbamimidamido-4-methylbenzoate nitrate, NINGBO INNO PHARMCHEM CO.,LTD. stands as a trusted partner, offering both excellence in product and a commitment to customer satisfaction. Our aim is to support the pharmaceutical industry by providing reliable and high-purity chemical intermediates essential for drug development and manufacturing.