Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate, identified by CAS number 147118-35-2, is a highly specialized chemical compound playing a pivotal role in the synthesis of advanced pharmaceuticals. This intermediate is particularly significant in the production of Rosuvastatin, a widely prescribed medication used to manage cholesterol levels. Its precise molecular structure, C31H39O4PSi, and molecular weight of 534.69800 are critical for achieving the desired outcome in complex synthetic pathways.

The compound presents as a white or light yellow crystalline powder, indicative of its solid form and typically high purity. Its physical and chemical properties are well-defined, contributing to its reliability in manufacturing processes. These include a density of approximately 1.1 g/cm3, a boiling point of 603.9ºC at 760 mmHg, and a melting point range between 77.5-78.5ºC. The flash point is remarkably high at 319ºC, and the refractive index is measured at 1.553. These intrinsic properties are vital for process design, safety protocols, and ensuring consistent batch production.

Quality specifications for Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate are stringent to meet pharmaceutical standards. A typical specification requires a purity of ≥98.0%. Loss on drying must be kept low, typically ≤2.0%, and single impurities are controlled to a maximum of 1.0%. As a chiral intermediate, its specific optical rotation is a crucial indicator of its stereochemical integrity, specified between -5.2º to -7.2º. Adhering to these specifications ensures that the downstream synthesis of Rosuvastatin proceeds efficiently and yields a product meeting the required purity and stereochemistry.

The primary application of this intermediate is in the sophisticated synthetic route towards Rosuvastatin. Rosuvastatin Calcium is a potent statin drug, effective in lowering LDL cholesterol and triglycerides, thereby reducing the risk of cardiovascular diseases. The synthesis of Rosuvastatin involves multiple steps, often employing elegant chemical transformations like the Wittig reaction, where the triphenylphosphoranylidene group on this intermediate is instrumental in forming a crucial carbon-carbon double bond with precise control over stereochemistry. The (3R) configuration of the silyloxy group is also essential for building the correct chiral center required in the final drug molecule. The reliable supply of this high-quality intermediate is therefore indispensable for pharmaceutical companies manufacturing Rosuvastatin globally.

NINGBO INNO PHARMCHEM CO.,LTD. understands the critical need for high-quality pharmaceutical intermediates like Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate. We are committed to providing materials that meet rigorous purity standards and consistent specifications required for drug synthesis. Our manufacturing processes are designed to ensure batch-to-batch reproducibility and stability. The material is typically packaged in 25kg cardboard drums or can be customized according to specific customer requirements, with storage recommendations emphasizing a cool, dry, well-ventilated area in a tightly closed container, away from incompatible substances, to maintain its quality and integrity over time.

As a trusted manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. ensures a consistent and high-quality supply of this crucial intermediate. For inquiries regarding the price, specifications, or to buy or purchase this compound, reliable supply is available.