Methylmagnesium Chloride, identified by its CAS number 676-58-4 and chemical formula CH3MgCl, stands as a cornerstone in modern organic chemistry. As the simplest Grignard reagent, this organometallic compound is indispensable for a myriad of synthetic transformations. Although inherently a colorless solid, it is most commonly supplied and utilized as a solution in inert solvents like tetrahydrofuran (THF) or diethyl ether, ensuring its stability and ease of handling in laboratory and industrial settings.

One of the defining characteristics of Methylmagnesium Chloride is its exceptional reactivity. It is a highly flammable substance and exceptionally moisture sensitive, reacting violently with water and other protic reagents to produce methane. This vigorous reactivity underscores its power as a nucleophile and a strong base, making it a valuable tool for forming new carbon-carbon bonds and introducing methyl groups into organic molecules. Its molar mass is approximately 74.79 g/mol.

The synthesis of Methylmagnesium Chloride typically involves the reaction of methyl chloride with magnesium metal in an ethereal solvent. This process, a classic example of Grignard reagent formation, is crucial for obtaining the compound in a reactive form. In donor solvents, Methylmagnesium Chloride is highly solvated, with magnesium often exhibiting a tetrahedrally bonded center through coordination with solvent oxygen atoms. This structural aspect is key to its stability and reactivity in solution.

As a synthetic equivalent to the methyl carbanion synthon, Methylmagnesium Chloride plays a pivotal role in various chemical reactions. It is widely employed in:

• Grignard reactions: For the formation of alcohols from aldehydes and ketones, or carboxylic acids from carbon dioxide.
• Methylation: Introducing methyl groups into complex organic structures.
• Cross-coupling reactions: Specifically in nickel-catalyzed processes such as the alkenation of dithioacetals, and cross-coupling with aryl triflates, carbamates, and vinyl selenides.

Its advantages often include its relatively low equivalent weight and competitive pricing, making it an attractive option over some other methylmagnesium halides for certain applications.

Given its potent reactivity, the handling of Methylmagnesium Chloride demands stringent safety protocols. It is categorized as a hazardous substance due to its flammability and corrosiveness. Hazard statements include H225 (Highly flammable liquid and vapor), H250 (Catches fire spontaneously if exposed to air), H260 (In contact with water releases flammable gases which may ignite spontaneously), H314 (Causes severe skin burns and eye damage), and H336 (May cause drowsiness or dizziness). Precautionary measures such as keeping away from heat and open flames, handling under inert gas, protecting from moisture, and wearing appropriate personal protective equipment (gloves, protective clothing, eye protection, face protection) are absolutely essential. Immediate action, such as rinsing skin with water/shower and seeking medical attention, is required in case of exposure. Furthermore, users should be aware that it may form explosive peroxides and reacts violently with water.

For researchers and industrial entities seeking this fundamental chemical, finding a reliable Methylmagnesium Chloride manufacturer and supplier is paramount. Quality and consistency are critical for successful synthetic outcomes. When you intend to buy or purchase Methylmagnesium Chloride, it is advisable to consider a producer with a strong reputation for purity and adherence to safety standards. Obtaining a competitive Methylmagnesium Chloride price often involves sourcing directly from established chemical manufacturers who specialize in organometallic compounds. Such companies can provide the technical support and product specifications necessary for its effective and safe application in diverse chemical synthesis projects.