Metronidazole Benzoate, identified by CAS number 13182-89-3, stands as a significant pharmaceutical raw material, primarily utilized for its potent antitrichomonal and anti-infective properties. Chemically known as 1-(2-benzoylxyethyl)-2-methyl-5-nitroimidazole, it is the benzoic acid ester of Metronidazole. This esterification is often employed to improve the pharmacokinetic profile or enhance the palatability and stability of the active compound, particularly in liquid formulations intended for pediatric or oral use. As a fine, micronized powder, Metronidazole Benzoate is a versatile ingredient for various pharmaceutical applications.

The primary indication for which Metronidazole Benzoate powder is sought is in the treatment and prevention of infections caused by susceptible anaerobic bacteria and certain protozoa, including Trichomonas vaginalis. Its efficacy stems from the parent compound, Metronidazole, which enters the target organism and undergoes reduction. This reduced form is cytotoxic, damaging DNA and other vital biomolecules, leading to cell death. The benzoate form acts as a prodrug, being hydrolyzed in the body to release the active Metronidazole.

Strict quality control is paramount for pharmaceutical raw materials like Metronidazole Benzoate. High purity, typically exceeding 99.0%, is essential to ensure the safety and efficacy of the final drug product. Compliance with major pharmacopoeial standards, such as USP (United States Pharmacopeia) and BP (British Pharmacopoeia), is a critical requirement. Manufacturing facilities producing this material must adhere to stringent quality management systems like ISO 9001 and potentially GMP (Good Manufacturing Practice), although GMP is more commonly applied to finished drug products or API production directly used in dosage forms. The physical characteristics, such as appearance (white to light yellow powder) and particle size (micronized), are also controlled to ensure consistent performance in downstream processing and formulation.

The production process for Metronidazole Benzoate involves the esterification of Metronidazole with benzoic acid or a derivative. This chemical synthesis requires precise control of reaction conditions, purification steps, and analytical testing to yield a product meeting pharmaceutical specifications. The resulting powder is then subjected to rigorous quality testing, including assays for purity, identification tests, tests for impurities, and physical property evaluations.

Packaging of pharmaceutical raw materials must protect the product from environmental factors like moisture, light, and contamination. Common packaging options for Metronidazole Benzoate powder include aluminium foil bags, which provide excellent moisture barrier properties, followed by outer packaging such as cartons or fibre drums for larger quantities. These packaging types are chosen based on the quantity ordered and transportation requirements, ensuring the product's integrity from the manufacturing site to the customer's facility. A typical shelf life for Metronidazole Benzoate under proper storage conditions is around two years, but this can vary depending on specific manufacturing and packaging methods.

Logistics for transporting pharmaceutical raw materials demand careful handling and adherence to regulations. For smaller sample sizes or urgent requirements, express services like DHL, UPS, FedEx, or TNT are commonly used due to their speed and global reach. For larger bulk orders, shipping by air, sea, or train is more economical. Suppliers often provide flexible shipping options, including DDP (Delivered Duty Paid) services, to simplify the import process for customers in various regions.

Sourcing reliable pharmaceutical raw materials is a critical decision for drug manufacturers. Factors such as product quality, consistency, regulatory compliance, production capacity, lead time, and pricing are key considerations. Working with experienced manufacturers who have a proven track record and robust quality systems helps ensure a stable and compliant supply chain.

For businesses seeking to buy Metronidazole Benzoate or purchase Metronidazole Benzoate, identifying a reputable Metronidazole Benzoate manufacturer and Metronidazole Benzoate supplier is the first step. Inquiring about the Metronidazole Benzoate price typically involves contacting suppliers with details of the required quantity, desired quality standards (e.g., USP, BP), and delivery destination. Minimum order quantities, often starting from 25kg for bulk powder, are standard in the industry. Establishing direct communication allows for clarification of specifications, sampling procedures, lead times, and payment terms. Finding a partner with strong R&D capabilities can also be beneficial for customized requirements or technical support. Ultimately, a reliable supplier ensures that pharmaceutical companies can confidently formulate effective and safe medications.