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Montelukast Intermediate Synthesis: A Deep Dive into Quality and Efficacy

In the complex landscape of pharmaceutical manufacturing, the quality of intermediates directly dictates the efficacy and safety of the final drug product. One such crucial compound is (S)-Methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate, identified by CAS number 142569-69-5. This molecule serves as a pivotal building block in the synthesis of Montelukast Sodium, a widely prescribed medication for managing asthma and allergic rhinitis. Understanding its synthesis and the rigorous quality control measures applied is paramount for pharmaceutical companies seeking reliable sourcing.

The synthesis of montelukast intermediate involves a multi-step process that demands precision, particularly in achieving the correct stereochemistry. The (S)-configuration of the hydroxyl group is essential for Montelukast's high-affinity binding to the CysLT₁ receptor, which is the basis of its therapeutic action. Pharmaceutical manufacturers in China, known for their advanced chemical synthesis capabilities, play a significant role in supplying this high-purity intermediate. When seeking to purchase this compound, it is vital to partner with a reputable supplier that can guarantee consistent quality and adherence to stringent international standards.

As a leading producer, NINGBO INNO PHARMCHEM CO.,LTD. prioritizes excellence in every batch. Our commitment extends to ensuring that every kilogram of this chemical intermediate meets the required purity specifications, typically exceeding 98%. The manufacturing process often incorporates advanced techniques such as biocatalytic reduction, which allows for highly stereoselective synthesis, minimizing impurities and maximizing yield. This focus on precision in the synthesis of montelukast intermediate ensures that downstream processes for Montelukast production are streamlined and efficient.

The demand for Montelukast remains consistently high globally, making the reliable supply of its precursors a critical component of the healthcare supply chain. Pharmaceutical companies often look for suppliers in China due to the cost-effectiveness and scale of production available. However, the emphasis must always remain on the quality and reliability of the chemical intermediate itself. Factors such as low heavy metal content (typically ≤20ppm) and controlled water levels (≤5%) are non-negotiable for pharmaceutical applications. These specifications, diligently maintained by experienced manufacturers, are key indicators of a product's suitability for API (Active Pharmaceutical Ingredient) synthesis.

For companies involved in the synthesis of montelukast sodium, sourcing this intermediate from a trusted manufacturer in China offers a strategic advantage. It ensures not only competitive pricing but also access to a product that has undergone rigorous quality checks. Investing in high-quality montelukast precursor is an investment in the efficacy and safety of the final medication, ultimately benefiting patients worldwide. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being that trusted partner, providing the essential chemical intermediates that drive pharmaceutical innovation.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

Professional Export Experience

to Global Customers

WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

CONTACT US
Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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