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In the dynamic field of pharmaceutical chemistry, the availability of high-quality intermediates is fundamental to the successful development of new therapeutics. N-(2-hydroxyethyl)pyridine-3-carboxamide (CAS: 6265-73-2) is a notable example of such an intermediate, valued for its unique structure and synthetic potential. As a compound related to pyridine carboxamides, it serves as a crucial building block in various organic synthesis pathways, particularly within the pharmaceutical sector.
The synthesis of N-(2-hydroxyethyl)pyridine-3-carboxamide typically involves the reaction of nicotinic acid or its esters with 2-aminoethanol (ethanolamine). This process, when optimized by experienced manufacturers, yields a product with a purity often exceeding 97%. Key physical properties include its appearance as a white to pale yellow solid, a melting point of approximately 92°C, and a predicted density of 1.212 g/cm³. These characteristics are vital for chemists to understand when planning synthetic strategies or evaluating potential suppliers.
The significance of N-(2-hydroxyethyl)pyridine-3-carboxamide in pharmaceutical research stems from its role as a precursor. It is instrumental in the synthesis of oxadiazole oxide derivatives, a class of compounds explored for various pharmacological activities. Its structural similarity to Nicorandil, a well-known antianginal drug, also positions it as an important compound for generating related impurities or reference standards, which are indispensable for drug quality control and regulatory compliance. For researchers aiming to buy N-(2-hydroxyethyl)pyridine-3-carboxamide, ensuring high purity is non-negotiable.
Procuring this intermediate efficiently often means looking towards global chemical suppliers, with many specialized companies in China offering competitive pricing and significant manufacturing capacity. When seeking to purchase N-(2-hydroxyethyl)pyridine-3-carboxamide, businesses should request detailed technical specifications and competitive quotes. A reliable N-(2-hydroxyethyl)pyridine-3-carboxamide manufacturer will not only provide the chemical but also the assurance of quality and consistency needed for critical pharmaceutical synthesis projects.
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