N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine, identified by its Chemical Abstracts Service (CAS) number 162012-67-1, stands as a critical and highly sought-after intermediate in the pharmaceutical industry. This compound, often referred to by its synonyms such as N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine or 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-, plays an indispensable role in the synthesis of advanced therapeutic agents, particularly in oncology.

Chemically, N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine possesses a molecular formula of C14H7ClF2N4O2, with a molecular weight of approximately 336.68100. Its physical and chemical profile is well-defined: it typically appears as an orange yellow solid powder. Key physical characteristics include a density of 1.617 g/cm³, a boiling point estimated around 488.589ºC, and a flash point of 249.29ºC, with an index of refraction at 1.707. These stable properties ensure its reliability and consistent performance in complex chemical processes.

Quality and purity are paramount for pharmaceutical intermediates. NINGBO INNO PHARMCHEM CO.,LTD. prides itself on supplying N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine that meets stringent quality specifications, typically achieving a purity of greater than or equal to 99.0%, with total impurities maintained at less than or equal to 1.0%. This high level of purity is crucial for ensuring the efficacy and safety of the final drug product. Standard packaging is in 25 kg drums, although custom packaging options are available to meet specific customer requirements. Proper storage in a cool, ventilated place is recommended to maintain its chemical integrity and extend shelf life.

The primary application of N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine lies in its function as a pivotal intermediate for the synthesis of Afatinib. Afatinib is a targeted therapy, specifically an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, widely used in the treatment of certain types of non-small cell lung cancer (NSCLC). The demand for high-quality intermediates like this compound directly correlates with the growing need for effective cancer treatments globally. Its unique chemical structure makes it an ideal precursor for building the complex molecular framework of Afatinib, contributing to the development of life-saving medications.

As a leading manufacturer and supplier of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine to meet the global market's needs. We ensure a consistent supply chain and offer competitive price structures for bulk purchase. Companies looking to buy or purchase this essential chemical intermediate can rely on our expertise and commitment to excellence. Our production adheres to rigorous quality control standards, ensuring that every batch supplied is of the highest caliber, supporting the seamless progression of your pharmaceutical synthesis projects.

Understanding the critical role of N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine in drug synthesis, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes safety and regulatory compliance in its manufacturing and handling processes. Our technical support team is available to assist clients with specific application requirements and provide comprehensive product information. For detailed specifications, current price information, or to inquire about bulk purchase options, please contact our sales department. We are committed to being your reliable partner for high-quality pharmaceutical intermediates.