In the vast landscape of organic chemistry, certain molecules stand out for their utility as versatile building blocks. N-(4-Hydroxyphenyl)thiourea, identified by its CAS number 1520-27-0, is one such compound. This article provides a comprehensive overview of its key chemical properties, its primary applications, and why it's a valuable asset for chemists and researchers looking to buy organic intermediates. Whether you are involved in pharmaceutical development, material science, or fine chemical synthesis, understanding this molecule is beneficial.

Chemical Profile of N-(4-Hydroxyphenyl)thiourea
N-(4-Hydroxyphenyl)thiourea is an organic compound with the molecular formula C7H8N2OS and a molecular weight of 168.22 g/mol. Key physical and chemical properties include:

* Appearance: Typically appears as a white to gray solid.

* Melting Point: A sharp melting point of 214 °C, indicating high purity and crystalline structure.

* Purity: Commonly available with a purity of 95% minimum, with higher grades also accessible for specialized applications.

* Stability: Generally stable under normal temperature and pressure conditions.

These characteristics make it a reliable reagent for various chemical transformations. Its structure, featuring a thiourea moiety and a hydroxyphenyl group, offers reactive sites amenable to diverse synthetic pathways.

Primary Applications in Synthesis
The most significant application of N-(4-Hydroxyphenyl)thiourea is as a crucial intermediate in the synthesis of the sphingosine kinase inhibitor, (SKI II). This derivative has demonstrated promising results in pre-clinical cancer research, showing oral bioavailability and significant tumor growth inhibition. Therefore, the demand for high-quality N-(4-Hydroxyphenyl)thiourea remains strong within the pharmaceutical R&D sector.

Beyond its role in (SKI II) synthesis, N-(4-Hydroxyphenyl)thiourea can potentially serve as a building block in other areas of organic synthesis, including:

* Development of novel heterocyclic compounds.

* Creation of custom ligands or catalysts.

* Research into new agrochemical or material science applications.

Its versatile structure allows chemists to explore various derivatizations and incorporate it into more complex molecular architectures. For those looking to purchase this intermediate, it's important to consider the purity and the reputation of the manufacturer.

Sourcing and Procurement Considerations
When sourcing N-(4-Hydroxyphenyl)thiourea (CAS 1520-27-0), it is advisable to work with established suppliers and manufacturers, particularly those based in China, known for their robust chemical production capabilities. Prioritize suppliers who can provide detailed specifications, Certificates of Analysis (CoA), and offer competitive prices for your required quantities. Whether for laboratory research or larger-scale production, a reliable supply chain is essential.

Conclusion
N-(4-Hydroxyphenyl)thiourea (CAS 1520-27-0) is a valuable organic intermediate with a well-defined chemical profile and significant applications, particularly in pharmaceutical synthesis. Its availability in high purity makes it an attractive option for chemists aiming for efficient and reproducible reactions. By understanding its properties and sourcing it from reputable suppliers, you can effectively leverage this versatile molecule in your chemical synthesis endeavors.