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N-(4-Oxocyclohexyl)phthalimide: A Key Intermediate for Pramipexole Synthesis

N-(4-Oxocyclohexyl)phthalimide, identified by its CAS number 104618-32-8, is a highly specialized chemical compound integral to the pharmaceutical industry. Known by several synonyms including 4-Phthalimidocyclohexanone, 2-(4-oxocyclohexyl)isoindole-1,3-dione, and N-(4-Oxocyclohexyl)phthalimide, this compound serves a pivotal role as an intermediate in the synthesis of critical medications. Its molecular formula, C14H13NO3, and a molecular weight of 243.25800 signify its complex yet stable chemical structure, making it an invaluable asset in the realm of fine chemical manufacturing. The significance of this compound primarily lies in its utility for producing Pramipexole and its dihydrochloride variant, both of which are essential in the treatment of various neurological disorders. NINGBO INNO PHARMCHEM CO.,LTD. is committed to manufacturing this product to stringent quality standards, serving global pharmaceutical needs with precision and reliability.


The chemical and physical characteristics of N-(4-Oxocyclohexyl)phthalimide highlight its suitability for demanding applications. It exhibits a density of approximately 1.357 g/cm³, indicating its molecular compactness. With a high boiling point of 409.96ºC at standard atmospheric pressure (760 mmHg), the compound demonstrates excellent thermal stability, which is crucial for various synthesis processes. Its flash point, recorded at 191.1±19.1°C, suggests moderate volatility, while a refractive index of 1.627 points to its specific optical properties, which can be useful in analytical verification. Visually, N-(4-Oxocyclohexyl)phthalimide appears as a white to off-white powder, a characteristic consistent with its high purity specification of ≥98%. Maintaining this high purity is paramount for its sensitive pharmaceutical applications. Proper storage conditions are essential to preserve its integrity: it should be stored in a cool, dry, and well-closed container, away from moisture and strong light or heat.


One of the primary applications of N-(4-Oxocyclohexyl)phthalimide is its indispensable role as an intermediate for Pramipexole (CAS: 104632-26-0) and Pramipexole dihydrochloride (CAS: 104632-25-9). Pramipexole, a well-known dopamine agonist, is widely prescribed for the effective management of Parkinson's disease and restless legs syndrome. The intricate synthesis of these vital drugs heavily relies on the structural integrity and precise chemical reactivity offered by N-(4-Oxocyclohexyl)phthalimide, facilitating key reactions within the production pathway. The compound's cyclohexanone backbone, skillfully combined with the phthalimido group, provides a stable yet reactive platform for subsequent chemical modifications. This unique dual nature significantly enhances its versatility, allowing chemists to accurately tailor it for specific therapeutic outcomes. For companies engaged in sourcing pharmaceutical intermediates, partnering with a supplier capable of providing such high-quality materials ensures streamlined drug development processes.


To ensure the sustained quality and effectiveness of N-(4-Oxocyclohexyl)phthalimide, meticulous attention is paid to its packaging and storage. The compound is typically supplied in 25kg cardboard drums, although custom packaging arrangements can be made to meet specific client requirements. These flexible packaging options underscore a commitment to accommodating diverse industry demands. Storage conditions are equally, if not more, critical. Exposure to moisture or excessive heat can significantly compromise the compound's stability, directly impacting its performance in downstream applications. Manufacturers and suppliers must therefore prioritize controlled environments to meticulously preserve the compound's characteristic white to off-white appearance and its crucial ≥98% purity. By rigorously adhering to these stringent storage standards, NINGBO INNO PHARMCHEM CO.,LTD. ensures that its clients consistently receive a product that performs reliably in their complex processes.


Beyond its well-established role in Pramipexole synthesis, N-(4-Oxocyclohexyl)phthalimide holds considerable potential in other chemical synthesis pathways within the broader fine chemicals sector. Its robust chemical properties, including high thermal stability and predictable reactivity, make it suitable for a variety of demanding applications. The global demand for such specialized intermediates is experiencing a steady increase, primarily driven by the pharmaceutical industry's continuous need for innovative treatments for chronic conditions. In China, the production of this vital compound is supported by advanced manufacturing techniques, ensuring both scalability and cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD. leverages cutting-edge technology to meet this escalating demand, consistently offering a product that adheres to rigorous international quality benchmarks. This strategic approach firmly establishes the company as a key player in the supply chain, efficiently serving both domestic and international markets.


When considering to buy N-(4-Oxocyclohexyl)phthalimide, understanding the price structures and securing a reliable supplier or manufacturer is paramount. NINGBO INNO PHARMCHEM CO.,LTD. stands as a distinguished manufacturer and supplier of this essential compound, renowned for its expertise in the research, development, and production of fine chemicals and pharmaceutical intermediates. The company excels in continuous flow process development and equipment manufacturing, boasting a dedicated pilot workshop and a robust network of external large-scale production platforms. Our strengths encompass handling complex reaction types, including high-temperature, high-pressure, nitration, oxidation, and continuous distillation processes. We offer comprehensive R&D and manufacturing services for a diverse array of compounds—such as bromides, boric acids, thiophenes, indoles, imidazoles, thiazoles, piperazines, and pyrazines—available in volumes ranging from ton to hundred-ton lots. Our focus is on products with annual volumes typically between 100 kgs and 100 metric tons, often involving up to five sophisticated synthetic steps. For those looking to purchase high-purity N-(4-Oxocyclohexyl)phthalimide, inquiring directly about the latest price and availability from a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. is recommended to ensure quality, reliability, and timely delivery for your specific needs.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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