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N-Acetyl-D-mannosamine (ManNAc) is a biochemical compound that has drawn significant attention in the medical community for its potential therapeutic applications. As a key precursor in the biosynthesis of sialic acids, which are vital components of glycoproteins and glycolipids, ManNAc plays a crucial role in cellular communication, immune response, and cellular protection.
One of the most promising areas of research for N-Acetyl-D-mannosamine is its application in treating Congenital Disorders of Glycosylation (CDG), a group of rare metabolic disorders. Specifically, ManNAc is being investigated for its efficacy in managing GNE myopathy, a genetic muscle disorder caused by mutations in the GNE gene. This gene encodes an enzyme critical for sialic acid synthesis. Patients with GNE myopathy experience progressive muscle weakness and atrophy. Supplementation with N-Acetyl-D-mannosamine has demonstrated promise in preclinical studies to restore normal sialic acid levels and potentially improve muscle function. For researchers and pharmaceutical companies looking to buy N-Acetyl-D-mannosamine for GNE myopathy treatment, sourcing from a reliable CAS 7772-94-3 manufacturer in China is paramount.
The mechanism of action of N-Acetyl-D-mannosamine revolves around its role in the sialylation pathway. By facilitating the biosynthesis of sialic acids, ManNAc helps maintain and enhance the functions of cell surface molecules. When administered, ManNAc is phosphorylated within cells and converted into N-acetylneuraminic acid (Neu5Ac), the most common sialic acid. This increased availability of Neu5Ac leads to enhanced sialylation, which can ameliorate symptoms in conditions where sialylation is impaired.
Beyond GNE myopathy, N-Acetyl-D-mannosamine is also being explored for its potential in other conditions where sialylation is implicated, such as certain cancers, autoimmune diseases, and viral infections. The ability to improve age-related cognitive decline also presents an avenue for neurological health applications. This versatility underscores its importance as a pharmaceutical intermediate.
For procurement managers and R&D scientists seeking to integrate this compound into their development pipelines, understanding the N-Acetyl-D-mannosamine price for research is key. As a leading N-Acetyl-D-mannosamine supplier, we are committed to providing high-purity products to support groundbreaking research. Contact us today to purchase N-Acetyl-D-mannosamine and advance your therapeutic development.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
