N-Fluorobenzenesulfonimide (NFSI), identified by CAS Number 133745-75-2 and with the molecular formula C12H10FNO4S2, stands as a pivotal compound in modern organic synthesis. This white crystalline substance, often recognized by synonyms such as N-Fluoro-N-(phenylsulfonyl)benzenesulfonamide or N-Fluorobis(phenylsulfonyl)amine, boasts a molecular weight of 315.341. Its distinct physical properties include a melting point of 114-116 °C, a boiling point of 244.5 °C at 760 mmHg, a density of 1.476 g/cm3, and a flash point of 101.7 °C. NFSI exhibits excellent solubility in common organic solvents like acetonitrile, dichloromethane, and THF, albeit with reduced solubility in toluene, making it highly adaptable for various reaction conditions.

As a leading electrophilic fluorinating agent, N-Fluorobenzenesulfonimide plays a crucial role in introducing fluorine atoms into a wide array of organic molecules. Its versatility is demonstrated in its ability to facilitate monofluorination reactions on electron-rich aromatic compounds, enol silyl ethers, and enol lithium salts with high efficiency and yield. Beyond simple fluorinations, NFSI is instrumental in more complex synthetic pathways. It is utilized for the diastereoselective fluorination of lithium enolates of chiral carboximides and for the directed fluorination of ortho-lithiated aromatics, enabling precise control over reaction outcomes. Furthermore, asymmetric fluorinations can be achieved with NFSI in the presence of specific catalyst systems, such as palladium-BINAP complexes, operating effectively at room temperature in ionic liquids. This makes NFSI an indispensable tool for synthesizing chiral fluorinated compounds with high enantioselectivity.

The applications of N-Fluorobenzenesulfonimide extend across diverse industrial sectors. In the pharmaceutical research and development field, NFSI is vital for synthesizing fluorinated drug intermediates and active pharmaceutical ingredients, contributing to the creation of new therapeutic agents with enhanced pharmacokinetic profiles. Its utility is also pronounced in the manufacture of new materials, where the introduction of fluorine can impart unique properties such as thermal stability, hydrophobicity, and chemical inertness. Moreover, NFSI is a key reagent in the development of new pesticides, allowing for the synthesis of advanced agrochemicals with improved efficacy and environmental compatibility. Recent studies have highlighted its capacity as a metal-free sulfonyl donor for the synthesis of diarylsulfones, an efficient oxidant for trideuteromethylthiolation reactions, and even as an effective nitrogen source for regioselective amidation reactions, further broadening its synthetic scope.

Given its critical importance, sourcing high-purity N-Fluorobenzenesulfonimide is paramount for research and industrial applications. As a reliable manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering top-tier fluorochemical products, including NFSI. We establish a comprehensive fluorochemical platform, encompassing everything from fluorine-containing raw material procurement and advanced fluorination technology research and development to stringent product quality control and diverse application support. Our integrated approach ensures a seamless and convenient one-stop service for our global clientele. To inquire about the current price or to buy / purchase N-Fluorobenzenesulfonimide, please contact us directly. We guarantee superior quality and consistent supply to meet your specific requirements in the pharmaceutical, new materials, and agrochemical industries.