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Our genetic material, DNA, is constantly under assault from both internal and external factors, leading to damage that can accumulate over time. Fortunately, our cells are equipped with sophisticated DNA repair systems, and Nicotinamide Adenine Dinucleotide (NAD+) is a critical component of these processes. NAD+ acts as a vital cofactor and substrate for enzymes essential for maintaining the integrity of our DNA, playing a crucial role in safeguarding our genetic blueprint.
One of the most significant pathways involving NAD+ in DNA repair is mediated by Poly (ADP-ribose) polymerases, commonly known as PARPs. When DNA damage occurs, PARP enzymes are activated and utilize NAD+ as a substrate to synthesize long chains of ADP-ribose. This process, called ADP-ribosylation, is a key signaling event that recruits other repair proteins to the site of damage and facilitates the repair process. Essentially, NAD+ provides the building blocks for the cell to initiate and carry out DNA repair.
The importance of NAD+ in DNA repair becomes even more apparent when considering the aging process. As we age, DNA damage tends to accumulate, partly due to the natural decline in NAD+ levels. This reduction in NAD+ can impair the efficiency of DNA repair mechanisms, leading to increased genomic instability, which is a hallmark of aging and a contributor to various age-related diseases. Therefore, strategies aimed at maintaining or increasing NAD+ levels are also strategies that can support the cell's ability to repair DNA damage effectively.
Beyond PARPs, NAD+ also influences other cellular processes that contribute to overall cellular health and resilience, indirectly supporting DNA integrity. The continuous need for DNA repair underscores the importance of adequate NAD+ availability. Understanding the intricate relationship between NAD+ DNA repair mechanisms highlights a fundamental aspect of cellular maintenance and healthy aging, emphasizing the coenzyme's critical role in preserving our genetic code.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
