Naringenin (CAS: 480-41-1), a prominent naturally occurring flavanone found abundantly in citrus fruits like grapefruit, oranges, and even tomatoes, stands out as a powerful phytochemical with a wide array of health-promoting properties. This white solid compound, with a molecular formula of C15H12O5 and a molecular weight of 272.25, is recognized for its high purity levels, typically exceeding 98%. Its versatile biological activities make it a subject of extensive scientific research and a valuable compound in various industries.

One of the most significant aspects of Naringenin is its profound antioxidant and anti-inflammatory capabilities. It actively scavenges free radicals and enhances the activity of the body's natural antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT). This protective action extends to mitigating oxidative stress and inflammation, which are underlying factors in many chronic diseases. Its ability to inhibit pro-inflammatory cytokines and pathways, like NF-kB and MAPK, underscores its potential in managing inflammatory conditions.

Beyond its antioxidative effects, Naringenin has shown considerable promise in cancer research. Preclinical studies have explored its inhibitory effects on a wide range of cancer types, including colorectal, gastric, lung, breast, ovarian, cervical, prostate, bladder, liver, pancreatic, and skin cancers. Its mechanisms involve inducing apoptosis (programmed cell death), inhibiting cell proliferation and migration, and disrupting key signaling pathways involved in tumor growth and metastasis. For example, it can influence factors like cyclin D1, Akt, MMPs, and the JAK/STAT pathway, making it a multifaceted agent against various malignancies.

Naringenin's therapeutic potential also extends to metabolic disorders. It has demonstrated beneficial effects in models of diabetes by reducing blood glucose levels, improving insulin sensitivity, and enhancing glucose uptake in muscle cells. In cases of obesity and hyperlipidemia, Naringenin has been shown to reduce fat accumulation, lower cholesterol and triglyceride levels, and modulate lipid metabolism. Furthermore, its ability to alleviate hypertension by lowering blood pressure and influencing critical regulatory enzymes highlights its role in cardiovascular health. It also contributes to hepatic protection by inhibiting fat accumulation in the liver, offering promise for conditions like nonalcoholic fatty liver disease (NAFLD), and helps suppress atherosclerosis by improving blood lipid profiles and reducing arterial plaque buildup.

The benefits of Naringenin are not limited to physical health; it also exhibits remarkable neuroprotective properties. Research indicates its potential in addressing neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). In AD models, Naringenin has been observed to improve cognitive functions, regulate pathways like PI3K/Akt/GSK-3, and inhibit enzymes crucial to AD progression. For PD, it protects against oxidative damage caused by various neurotoxins and improves motor function, suggesting a role in preserving neuronal health.

Moreover, Naringenin and its derivatives possess notable antimicrobial and antifungal activities. It has shown efficacy against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), by disrupting bacterial membranes, inhibiting biofilm formation, and suppressing toxin production. While its activity against Gram-negative bacteria might be generally lower, modified Naringenin derivatives show enhanced potency. Against fungi, it can inhibit growth and even act synergistically with existing antifungal agents, indicating its potential in combating infectious diseases, especially those caused by drug-resistant pathogens.

As a leading manufacturer and supplier of high-quality Naringenin (CAS: 480-41-1), NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this versatile phytochemical for diverse applications. Our product undergoes stringent quality control to ensure its purity and efficacy. For detailed product specifications, price information, or to buy/purchase Naringenin in bulk, please reach out to our sales team. We offer competitive pricing and reliable worldwide delivery, ensuring you receive a premium product from a trusted supplier in the chemical industry.