4-Bromoaniline, identified by its CAS number 106-40-1, is a compound of considerable interest in organic chemistry due to its distinct properties and broad applicability. As a brominated derivative of aniline, it serves as a vital intermediate in the manufacturing of pharmaceuticals, dyes, agrochemicals, and other fine chemicals. Understanding its fundamental chemical properties and synthesis routes is crucial for any professional engaging with this compound.

Physically, 4-Bromoaniline typically appears as a white to off-white crystalline solid. Its molecular formula is C6H6BrN, with a molecular weight of approximately 172.02 g/mol. Key physical characteristics include a melting point range commonly cited between 66-68°C, though variations exist, and a boiling point of around 243°C. Its solubility in water is limited, but it readily dissolves in common organic solvents such as ethanol, ether, and chloroform, facilitating its use in various reaction media. These well-defined chemical properties of 4-bromoaniline are essential for predictable reaction outcomes.

The synthesis of 4-Bromoaniline can be achieved through several methods. A prominent preparation technique involves the amination of bromobenzene using hydrazine hydrate and iron oxide as catalysts in an ethanol solvent, often yielding 100%. Another common approach is the reduction of 4-nitrobromobenzene. The precise control of reaction conditions, temperature, and catalyst selection are critical to ensure high purity and yield, especially when producing for demanding applications where one might look to buy 4-bromoaniline.

The reactivity of 4-Bromoaniline stems from the presence of both the amino group and the bromine substituent on the aromatic ring. The amino group makes it a weak base and susceptible to electrophilic attack, while the bromine atom can be a site for nucleophilic substitution or participate in coupling reactions. This dual reactivity makes it a versatile building block in organic synthesis.

Safety considerations are paramount when handling 4-Bromoaniline due to its toxic nature. It is classified as harmful if swallowed, in contact with skin, or inhaled, and can cause skin and eye irritation. Therefore, proper handling procedures, including the use of PPE and working in well-ventilated areas, are indispensable. For those interested in the price of 4-bromoaniline, sourcing from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. ensures competitive pricing along with quality assurance.

NINGBO INNO PHARMCHEM CO.,LTD. is a prominent manufacturer and supplier of 4-Bromoaniline in China, offering high-purity material for a wide range of industrial applications. Our expertise in chemical synthesis ensures a reliable supply of this essential intermediate. For further information or to discuss your requirements for 4-bromoaniline, please reach out to us.