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Nifedipine, with CAS number 21829-25-4, is a vital pharmaceutical raw material in the form of a yellow crystalline powder. It belongs to the class of medications known as dihydropyridine calcium channel blockers. Its primary function is to treat and manage cardiovascular conditions, most notably angina pectoris and hypertension.
The mechanism of action for Nifedipine is both potent and specific. It inhibits the influx of calcium ions into vascular smooth muscle cells and heart muscle cells. This action leads to the relaxation and widening of blood vessels (vasodilation), particularly the coronary arteries and peripheral arterioles. By dilating the coronary arteries, Nifedipine increases the supply of oxygen-rich blood to the heart muscle, which is crucial for preventing the chest pain associated with angina. This is especially effective for treating variant angina, which is caused by coronary artery spasms.
Furthermore, its effect on peripheral arterioles lowers overall vascular resistance. This reduction in resistance leads to a decrease in blood pressure, making Nifedipine an effective agent for managing various forms of hypertension, including severe and refractory cases. A significant advantage is that Nifedipine generally does not negatively impact respiratory function, making it a suitable option for angina patients who also have obstructive respiratory diseases.
In addition to its primary applications, Nifedipine has also shown efficacy in treating refractory congestive heart failure. By reducing the afterload—the resistance the heart must pump against—it eases the workload on the heart, improving its function over the long term. The high purity and stable quality of Nifedipine powder are essential for its therapeutic effectiveness.
For those looking to buy this critical active pharmaceutical ingredient, it is important to source it from a reliable manufacturer. NINGBO INNO PHARMCHEM CO.,LTD. is a premier supplier of high-purity Nifedipine powder. We are committed to providing top-quality materials that meet rigorous pharmaceutical standards. If you are seeking a competitive price or wish to purchase Nifedipine powder, our company ensures excellence in both product and service, supporting the production of life-saving medications worldwide.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
