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Nigericin Sodium Salt: A Detailed Look at its Chemical Properties and Handling

At NINGBO INNO PHARMCHEM CO.,LTD., we understand that successful research hinges on the quality and proper handling of chemical reagents. This piece focuses on Nigericin Sodium Salt, detailing its key chemical properties and providing essential guidance for its use in the laboratory.

Nigericin Sodium Salt, with the chemical formula C40H67NaO11, possesses a molecular weight of approximately 746.94 g/mol. It is characterized as a polyether antibiotic and functions as a potent K+/H+ ionophore. Its structure allows it to selectively transport monovalent cations across membranes, with a known specificity order of K+ > Rb+ > Cs+ >> Na+.

In terms of physical form, Nigericin Sodium Salt is typically supplied as a white to off-white powder. Its solubility profile is an important consideration for experimental design. It is generally soluble in organic solvents such as DMSO and ethanol, while exhibiting limited solubility in water. For instance, it is soluble in DMSO at concentrations of 50 mg/ml and in ethanol at 20 mg/ml, but sparingly soluble in aqueous solutions.

Proper storage and handling are crucial to maintain the integrity and efficacy of Nigericin Sodium Salt. When stored in its lyophilized form, it remains stable for extended periods, typically up to 24 months when kept at 4°C and desiccated. Once reconstituted into a solution, it is recommended to store it at -20°C and use it within two months. To prevent degradation due to freeze-thaw cycles, it is advisable to aliquot the reconstituted solution into smaller volumes.

Researchers looking to purchase Nigericin Sodium Salt can rely on NINGBO INNO PHARMCHEM CO.,LTD. for high-purity products and comprehensive technical information. Understanding these chemical properties and adhering to recommended handling procedures ensures that experimental outcomes are reliable and reproducible, advancing scientific discovery.

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