NINGBO INNO PHARMCHEM CO.,LTD. is proud to present Nonivamide, a highly sought-after synthetic analog of capsaicin. Known scientifically as N-Vanillylnonanamide or Pelargonic Acid Vanillylamide (PAVA), and identified by CAS number 2444-46-4, this versatile compound offers a wide array of applications across various industries. As a white crystalline powder, Nonivamide stands out due to its unique blend of properties, delivering the characteristic "heat" sensation of chili peppers but with a generally milder profile compared to natural capsaicin, making it a preferred choice for controlled applications.

Nonivamide boasts a molecular formula of C17H27NO3 and a molecular weight of 293.40. It is largely odorless but imparts a distinct pungent, burning taste, a characteristic that defines its utility. Its melting point is approximately 54-59°C, and it shows good solubility in solvents like methanol and DMSO.

The primary mechanism through which Nonivamide exerts its effects is by activating the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor. This receptor, found predominantly in sensory neurons, acts as an ion channel. Upon activation by Nonivamide, TRPV1 facilitates the influx of calcium and sodium ions into the cell. This ion influx depolarizes the neuron, leading to the sensation of warmth or burning. Interestingly, repeated or prolonged exposure to Nonivamide can lead to the desensitization of the TRPV1 receptor. This process results in a reduced responsiveness to subsequent stimuli and is often accompanied by the depletion of neuropeptides such as Substance P. This desensitization mechanism is crucial for Nonivamide’s analgesic properties, particularly in pain management.

The multifaceted nature of Nonivamide makes it invaluable in several sectors.
In the pharmaceutical industry, it is widely utilized for its analgesic effects. Topical creams and ointments containing Nonivamide are effective in providing temporary relief from various pain conditions, including joint pain, neuralgia, rheumatism, arthritis, lumbago, muscular aches, sprains, and strains. Its ability to create a warming sensation is particularly beneficial for these applications. Research also indicates its potential role in broader health applications, such as contributing to formulations aimed at preventing cardiovascular disease or managing symptoms associated with coughs and colds.
The food and beverage industry leverages Nonivamide to impart a controlled hot sensation. It is a popular ingredient in flavoring agents, spice mixtures, and even certain confectionery products, offering a consistent and reproducible level of pungency.
Beyond these, Nonivamide finds utility in industrial and agricultural applications. It can be incorporated into anti-fouling paints for marine vessels, effectively deterring the growth of algae and shells. Furthermore, its irritant properties make it an active component in new biological pesticides and as an additive in materials like electric cables to prevent damage from rodents and insects. Its use in self-defense sprays, where its potent irritant effect can temporarily incapacitate, underscores its diverse range of functions.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of high-purity Nonivamide. Our production processes adhere to stringent quality control standards, ensuring that our Nonivamide powder (CAS 2444-46-4) consistently meets or exceeds purity specifications, typically over 98% (HPLC). We provide comprehensive Certificates of Analysis (COA) with every batch, guaranteeing the quality and reliability of our product.

For those looking to buy Nonivamide, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive prices and flexible packaging options to meet diverse client needs, from milligrams to metric tons. Whether you require small quantities for research and development or bulk supplies for industrial production, we are equipped to handle your orders efficiently. To inquire about specific product details, lead times, or to purchase Nonivamide, please contact our sales team. We are dedicated to providing excellent service and support to all our customers.

While generally safe for its intended uses, especially in topical applications, it is important to handle Nonivamide with care due to its irritant nature. Common, typically mild, side effects may include localized skin irritation, redness, or a transient burning sensation, which usually diminish with continued use as tolerance develops. Proper application and adherence to usage guidelines are always recommended.