NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing the highest quality active pharmaceutical ingredients (APIs) to the global healthcare market. Among the critical products in our portfolio is Nystatin, a well-established and powerful antifungal agent. This document explores the essential characteristics, mechanism of action, and diverse applications of Nystatin powder, a vital raw material in the fight against fungal infections.

Nystatin, identified by its CAS number 1400-61-9, is a polyene macrolide antibiotic derived from the bacterium Streptomyces noursei. It presents as a characteristic yellow to light tan powder. While its discovery dates back to 1950, its relevance in modern medicine has not waned. It remains a first-line defense, particularly against infections caused by various species of Candida yeast. Its chemical formula is C₄₇H₇₅NO₁₇, and its molecular weight is approximately 926.1 g/mol. A key physical property of Nystatin is its insolubility in water, which significantly influences its formulation and routes of administration.

Mechanism of Action: A Targeted Approach
The efficacy of Nystatin lies in its specific mode of action against fungal cells. Unlike many antibacterial agents, Nystatin targets a component unique to fungal and yeast cell membranes: ergosterol. Human cells, in contrast, utilize cholesterol in their membranes. This selective targeting is the foundation of Nystatin's therapeutic index, allowing it to be effective against fungi with minimal impact on host cells.

Nystatin works by binding securely to ergosterol. This binding event disrupts the integrity of the fungal cell membrane, creating pores or channels. The formation of these channels leads to an increased permeability of the membrane, causing essential intracellular constituents, particularly potassium ions ($K^+$), to leak out of the cell. This loss of vital ions disrupts the cell's osmotic balance and metabolic processes, ultimately leading to cell death. This action is fungicidal, meaning it actively kills the fungal cells, rather than simply inhibiting their growth (fungistatic). This robust, destructive mechanism makes Nystatin a reliable agent for resolving infections.

Applications of High-Purity Nystatin Powder
As a raw material, high-purity Nystatin powder is the starting point for numerous pharmaceutical preparations. Its poor absorption from the gastrointestinal tract dictates its primary use for topical and localized infections, where it can act directly at the site of infection without significant systemic exposure.

1. Oral Candidiasis (Thrush): One of the most common applications of Nystatin is in the treatment of oral thrush, a condition prevalent in infants, the elderly, and immunocompromised individuals. Nystatin is formulated as an oral suspension. Patients are instructed to swish the liquid in their mouths to ensure thorough contact with the oral mucosa before swallowing. This allows the API to eradicate the Candida albicans yeast responsible for the infection.

2. Cutaneous and Mucocutaneous Infections: Nystatin powder is incorporated into various topical formulations like creams, ointments, and powders to treat fungal infections of the skin. This includes conditions such as diaper rash caused by Candida, infections in skin folds (intertrigo), and other localized yeast infections. Its targeted action makes it highly effective for these surface-level ailments.

3. Gastrointestinal Infections: While not absorbed systemically, Nystatin taken orally is effective for treating fungal infections within the gastrointestinal tract. By passing through the intestines, it can eliminate yeast overgrowth without entering the bloodstream, minimizing the risk of systemic side effects.

4. Veterinary Medicine: The use of Nystatin is not limited to humans. It is also a valuable tool in veterinary medicine for treating similar fungal and yeast infections in a variety of animal species, ensuring the health and well-being of pets and livestock.

5. Cell Culture and Research: In laboratory settings, Nystatin is often used as a supplement in cell culture media to prevent fungal contamination, ensuring the integrity of research experiments.

The Importance of Quality and Purity
For any Active Pharmaceutical Ingredient, quality is paramount. At NINGBO INNO PHARMCHEM CO.,LTD., we understand that the purity and consistency of Nystatin powder directly impact the safety and efficacy of the final medicinal product. Our production processes adhere to stringent quality control standards to ensure that our Nystatin meets the highest pharmacopeial requirements, providing a reliable and effective raw material for our clients' formulation needs. Impurities or variations in potency can compromise patient outcomes, making a trusted source essential.

For pharmaceutical formulators and researchers looking to develop or manufacture antifungal treatments, securing a consistent and high-grade product is the first step. If you are looking for a premier Nystatin manufacturer or a reliable Nystatin supplier, it is critical to partner with a company that guarantees quality. When considering where to buy Nystatin powder, factors such as purity, regulatory compliance, and batch-to-batch consistency should be top priorities. To inquire about the price of Nystatin or to purchase bulk Nystatin raw material, engaging with an established supplier ensures you receive a product fit for clinical and pharmaceutical use. We are dedicated to being that trusted partner in the supply chain for this essential antifungal API.