Oleoyl Ethanolamide (OEA), scientifically known as N-(2-Hydroxyethyl)oleamide, is a fascinating endogenous lipid mediator gaining significant attention for its wide array of health benefits. With the chemical formula C20H39NO2 and a molecular weight of 325.52900, OEA presents as a white to off-white solid, demonstrating its purity typically at ≥98%. Its physical and chemical properties, including a melting point of 50-60°C and a boiling point of 496.4°C, highlight its stability and suitability for various applications.

At the core of OEA’s therapeutic potential lies its role as a high-affinity endogenous agonist for the peroxisome proliferator-activated receptor-alpha (PPAR-α). PPAR-α is a crucial nuclear receptor involved in regulating lipid metabolism and maintaining energy balance. By activating PPAR-α, OEA enhances the expression of genes related to fatty acid oxidation and lipolysis in adipose tissue and the liver. Beyond PPAR-α, OEA also interacts with other targets such as TRPV1 and GPR119, contributing to its diverse biological effects.

One of the most widely studied applications of OEA is in weight management and metabolic health. Research indicates that OEA effectively suppresses appetite and promotes satiety, leading to reduced food intake and increased fat burning. Clinical trials have demonstrated that OEA supplementation can significantly improve parameters such as body weight, body mass index (BMI), waist circumference, and fat mass. Furthermore, OEA shows promise in enhancing lipid metabolism, leading to a notable decrease in triglyceride levels. Its impact extends to glycemic control, with studies reporting significant reductions in fasting blood glucose (FBG), insulin levels, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).

OEA also exhibits potent anti-inflammatory and antioxidant properties. It has been shown to reduce inflammatory markers like C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α), while simultaneously boosting antioxidant capacities such as total antioxidant capacity (TAC) and superoxide dismutase (SOD). These effects contribute to its therapeutic potential in conditions associated with chronic inflammation and oxidative stress, including non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS). In PCOS, OEA has demonstrated an ability to improve glycemic status, oxidative stress, and inflammation, alongside a significant decrease in anti-Mullerian hormone (AMH) levels.

Beyond metabolic and inflammatory benefits, OEA also offers advantages in neurological health. Preclinical studies suggest neuroprotective effects, as OEA can block alcohol-induced pro-inflammatory cascades, reduce oxidative stress, and prevent neural damage. It has also shown antidepressant-like effects and the ability to reduce withdrawal symptoms and craving in models of alcohol abuse. This positions OEA as a promising compound for addressing neuroinflammation and certain mood-related disorders.

For industries seeking high-quality Oleoyl Ethanolamide, NINGBO INNO PHARMCHEM CO.,LTD. stands as a reliable manufacturer and supplier. We offer OEA with a purity of ≥98%, available in various packaging options including 1KG bags and 25KG drums, or customized to meet specific client needs. While OEA is generally considered safe with mild gastrointestinal discomfort being an uncommon side effect, continuous research is vital to determine optimal dosages and long-term benefits across various populations. For those looking to buy or purchase this innovative ingredient, competitive price options and flexible supply terms are available. As a leading supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing premium Oleoyl Ethanolamide to support advancements in health and wellness products worldwide.