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Optimizing Synthesis: The Role of High-Purity N-(2-hydroxyethyl)nicotinamide

In the intricate world of pharmaceutical synthesis, the quality of raw materials directly dictates the success and scalability of drug development. N-(2-hydroxyethyl)nicotinamide, also known by its CAS number 6265-73-2 and chemical name N-(2-hydroxyethyl)pyridine-3-carboxamide, is a prime example of a critical intermediate whose purity is paramount. For research scientists and production chemists, sourcing this compound from dependable manufacturers is not just a logistical step, but a foundational element for achieving desired outcomes.

The primary utility of N-(2-hydroxyethyl)nicotinamide lies in its role as a precursor for more complex molecular structures. It is particularly noted as an intermediate in the preparation of oxadiazole oxide derivatives, compounds that have shown promise in various therapeutic areas. Additionally, its structural relation to Nicorandil, an antianginal drug, makes it an important compound for research and the synthesis of related pharmaceutical standards or impurities. When you purchase N-(2-hydroxyethyl)nicotinamide, ensuring high purity levels (typically above 97%) is essential to minimize side reactions and purification challenges downstream.

Procurement teams often look for a trustworthy N-(2-hydroxyethyl)nicotinamide supplier capable of consistent quality and volume. This is where partnerships with established chemical companies, particularly those with strong manufacturing capabilities in regions like China, become advantageous. Obtaining a competitive price for N-(2-hydroxyethyl)nicotinamide from these sources can significantly impact the overall cost-effectiveness of your synthesis project. It is always advisable to request detailed specifications and analytical data when seeking a quote.

The synthesis process itself, as detailed in scientific literature, often involves reacting nicotinic acid derivatives with ethanolamine. The efficiency and yield of these reactions are highly sensitive to the quality of the starting materials. By choosing a high-purity N-(2-hydroxyethyl)nicotinamide, you reduce the risk of introducing unwanted byproducts that could complicate purification, lead to lower yields, or even compromise the final API's efficacy and safety. Therefore, identifying a reputable N-(2-hydroxyethyl)nicotinamide manufacturer is a critical first step in optimizing your synthetic routes.

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