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At NINGBO INNO PHARMCHEM CO., LTD., we understand that the success of a pharmaceutical formulation often hinges on the precise selection of excipients. Microcrystalline Cellulose (MCC) is a prime example, with its various grades offering distinct advantages for optimizing tablet performance. Understanding these differences is key to achieving desired tabletability, compressibility, and disintegration profiles, particularly in the context of microcrystalline cellulose direct compression processes.
MCC grades are typically differentiated by particle size, density, and other physical characteristics, which directly influence their performance in tablet manufacturing. For instance, grades with finer particle sizes, like MCC 101, are often preferred for wet granulation due to their excellent flow and binding properties, contributing to well-formed granules. On the other hand, grades with larger particle sizes and higher bulk densities, such as MCC 102 or MCC 200, are frequently chosen for direct compression applications. These grades provide superior flowability and compressibility, essential for producing robust tablets efficiently.
The choice of MCC grade can significantly impact tablet hardness, tensile strength, and friability. Higher compressibility grades generally lead to harder tablets, which can be advantageous for packaging and handling. However, it's also crucial to balance hardness with the tablet's ability to disintegrate effectively. The disintegrant properties of MCC are influenced by its particle structure and interaction with moisture, ensuring that tablets break down promptly upon ingestion for optimal API release. This is a critical aspect when considering the uses of MCC in pharmaceuticals, especially for immediate-release formulations.
Manufacturers often select specific MCC grades based on the characteristics of the API being formulated and the intended manufacturing process. For example, an API prone to lubrication issues might benefit from an MCC grade that offers inherent lubricity or improved flow. NINGBO INNO PHARMCHEM CO., LTD. offers a comprehensive range of MCC grades, enabling formulators to tailor their selections to specific product requirements. By understanding the nuanced microcrystalline cellulose properties and benefits associated with each grade, pharmaceutical companies can enhance tablet quality, streamline manufacturing, and ensure the reliable delivery of medications.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
