Ornipressin, a synthetic analog of the natural hormone vasopressin (also known as antidiuretic hormone), stands as a crucial pharmaceutical compound in various medical applications. With its chemical name 8-L-Ornithinevasopressin and CAS number 3397-23-7, it is recognized for its potent vasoconstrictive, hemostatic, and renal properties. This nonapeptide, characterized by its molecular formula C45H63N13O12S2 and a molecular weight of approximately 1042.19, presents as a white to off-white powder, indicating its purity and stability.

The physical and chemical properties of Ornipressin underscore its complex structure and biological activity. It exhibits a density of 1.3±0.1 g/cm3 and a high boiling point of 1616.2±65.0 °C at 760 mmHg, alongside a flash point of 931.3±34.3 °C. Its low vapor pressure (0.0±0.3 mmHg at 25°C) and an index of refraction of 1.583 further define its material characteristics. Meeting stringent specifications, Ornipressin typically boasts an assay of ≥98.0%, ensuring its high quality for pharmaceutical applications. For optimal preservation, it should be stored in a cool, ventilated place, safeguarding its integrity over time. NINGBO INNO PHARMCHEM CO.,LTD. adheres to these rigorous standards in the production and packaging of this vital compound, offering it in 25 kg drums or customized packaging tailored to specific customer requirements.

The primary mechanism of action for Ornipressin revolves around its ability to mimic vasopressin. It achieves its therapeutic effects predominantly by interacting with V1a receptors located on vascular smooth muscle cells. This binding triggers an intracellular cascade involving G-protein coupled receptors, leading to the activation of phospholipase C. Subsequently, this results in the conversion of phosphatidylinositol bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). The surge in IP3 then facilitates the release of calcium ions from intracellular stores. This increased intracellular calcium concentration is the critical trigger for smooth muscle contraction, culminating in profound vasoconstriction.

Through this powerful vasoconstrictive action, Ornipressin effectively narrows blood vessels, thereby reducing blood flow to specific regions. This property is invaluable in medical scenarios where controlling bleeding is paramount, such as during surgical procedures or endoscopic interventions. By minimizing blood loss, Ornipressin provides a clearer operational field for medical professionals. Furthermore, its vasoconstrictive capabilities make it a vital therapeutic option for managing conditions like esophageal varices, where it helps reduce the risk of rupture and bleeding by constricting dilated blood vessels, often seen in patients with liver cirrhosis and portal hypertension. Beyond its hemostatic roles, Ornipressin is also employed to manage hypotension, particularly during surgical procedures, and has shown promise in improving renal function in critically ill patients, albeit with a minor effect on V2 receptors that regulate water reabsorption in the kidneys.

While Ornipressin is highly effective, its use necessitates careful medical supervision due to its potent effects. Potential side effects can include hypertension, myocardial ischemia, arrhythmias, and peripheral ischemia, particularly if administered in excessive doses or to sensitive individuals. It is typically administered via intravenous injection, with dosage carefully tailored to the patient’s needs and the clinical context, ensuring rapid onset of action. Our company, NINGBO INNO PHARMCHEM CO.,LTD., is a dedicated manufacturer and supplier of high-quality Ornipressin. We ensure that our product meets global pharmaceutical standards, making us a reliable partner for those looking to buy or purchase this essential API. For detailed price information and to understand how our Ornipressin can serve your specific needs, please consider us as your trusted source for this critical compound.